論文 - 詳細
| RRC ID | 50286 |
|---|---|
| 著者 | Mandilaras K, Missirlis F. |
| タイトル | Genes for iron metabolism influence circadian rhythms in Drosophila melanogaster. |
| ジャーナル | Metallomics |
| Abstract |
Haem has been previously implicated in the function of the circadian clock, but whether iron homeostasis is integrated with circadian rhythms is unknown. Here we describe an RNA interference (RNAi) screen using clock neurons of Drosophila melanogaster. RNAi is targeted to iron metabolism genes, including those involved in haem biosynthesis and degradation. The results indicate that Ferritin 2 Light Chain Homologue (Fer2LCH) is required for the circadian activity of flies kept in constant darkness. Oscillations of the core components in the molecular clock, PER and TIM, were also disrupted following Fer2LCH silencing. Other genes with a putative function in circadian biology include Transferrin-3, CG1358 (which has homology to the FLVCR haem export protein) and five genes implicated in iron-sulfur cluster biosynthesis: the Drosophila homologues of IscS (CG12264), IscU (CG9836), IscA1 (CG8198), Iba57 (CG8043) and Nubp2 (CG4858). Therefore, Drosophila genes involved in iron metabolism are required for a functional biological clock. |
| 巻・号 | 4(9) |
| ページ | 928-36 |
| 公開日 | 2012-8-1 |
| DOI | 10.1039/c2mt20065a |
| PMID | 22885802 |
| MeSH | Animals Behavior, Animal / physiology Brain / metabolism Circadian Clocks / genetics Circadian Rhythm / genetics* Darkness Drosophila Proteins / genetics Drosophila Proteins / metabolism Drosophila melanogaster / genetics* Drosophila melanogaster / physiology* Gene Expression Regulation Genes, Insect / genetics* Genetic Association Studies Genetic Testing Iron / metabolism* Neurons / metabolism RNA Interference |
| IF | 3.796 |
| 引用数 | 39 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 14716R-1 14716R-3 |