Reference - Detail
| RRC ID | 50314 |
|---|---|
| Author | Inada K, Tsuchimoto Y, Kazama H. |
| Title | Origins of Cell-Type-Specific Olfactory Processing in the Drosophila Mushroom Body Circuit. |
| Journal | Neuron |
| Abstract |
How cell-type-specific physiological properties shape neuronal functions in a circuit remains poorly understood. We addressed this issue in the Drosophila mushroom body (MB), a higher olfactory circuit, where neurons belonging to distinct glomeruli in the antennal lobe feed excitation to three types of intrinsic neurons, α/β, α'/β', and γ Kenyon cells (KCs). Two-photon optogenetics and intracellular recording revealed that whereas glomerular inputs add similarly in all KCs, spikes were generated most readily in α'/β' KCs. This cell type was also the most competent in recruiting GABAergic inhibition fed back by anterior paired lateral neuron, which responded to odors either locally within a lobe or globally across all lobes depending on the strength of stimuli. Notably, as predicted from these physiological properties, α'/β' KCs had the highest odor detection speed, sensitivity, and discriminability. This enhanced discrimination required proper GABAergic inhibition. These results link cell-type-specific mechanisms and functions in the MB circuit. |
| Volume | 95(2) |
| Pages | 357-367.e4 |
| Published | 2017-7-19 |
| DOI | 10.1016/j.neuron.2017.06.039 |
| PII | S0896-6273(17)30563-9 |
| PMID | 28728024 |
| MeSH | Animals Calcium / metabolism* Drosophila melanogaster / physiology Mushroom Bodies / physiology* Neuroimaging / methods Neurons / physiology* Olfactory Bulb / physiology* Patch-Clamp Techniques / methods Smell* Synapses / metabolism |
| IF | 14.415 |
| Times Cited | 10 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 12 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | |