論文 - 詳細
| RRC ID | 50382 |
|---|---|
| 著者 | Sugihara A, Nguyen LC, Shamim HM, Iida T, Nakase M, Takegawa K, Senda M, Jida S, Ueno M. |
| タイトル | Mutation in fission yeast phosphatidylinositol 4-kinase Pik1 is synthetically lethal with defect in telomere protection protein Pot1. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
Fission yeast Pik1p is one of three phosphatidylinositol 4-kinases associated with the Golgi complex, but its function is not fully understood. Deletion of pot1+ causes telomere degradation and chromosome circularization. We searched for the gene which becomes synthetically lethal with pot1Δ. We obtained a novel pik1 mutant, pik1-1, which is synthetically lethal with pot1Δ. We found phosphoinositol 4-phosphate in the Golgi was reduced in pik1-1. To investigate the mechanism of the lethality of the pot1Δ pik1-1 double mutant, we constructed the nmt-pot1-aid pik1-1 strain, where Pot1 function becomes low by drugs, which leads to telomere loss and chromosome circularization, and found pik1-1 mutation does not affect telomere resection and chromosome circularization. Thus, our results suggest that pik1+ is required for the maintenance of circular chromosomes. |
| 巻・号 | 496(4) |
| ページ | 1284-1290 |
| 公開日 | 2018-2-19 |
| DOI | 10.1016/j.bbrc.2018.02.001 |
| PII | S0006-291X(18)30222-5 |
| PMID | 29410177 |
| MeSH | Apoptosis / genetics* Mutation / genetics* Phosphoproteins / genetics* Saccharomyces cerevisiae Proteins / genetics* Schizosaccharomyces / cytology Schizosaccharomyces / physiology* Schizosaccharomyces pombe Proteins / genetics* Telomere / genetics* |
| IF | 2.985 |
| 引用数 | 0 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 酵母 | |