Reference - Detail
| RRC ID | 50812 |
|---|---|
| Author | Takehana Y, Umekita M, Hatano M, Kato C, Sawa R, Igarashi M. |
| Title | Fradiamine A, a new siderophore from the deep-sea actinomycete Streptomyces fradiae MM456M-mF7. |
| Journal | J Antibiot (Tokyo) |
| Abstract |
New bioactive substances were identified from several marine actinomycetes strains by LC-HRESI-MS based non-targeted metabolomics. A new siderophore and its derivative, named fradiamines A and B, were isolated from the extract of the deep-sea actinomycetes Streptomyces fradiae MM456M-mF7 by Diaion CHP-20P, Sephadex LH-20 column chromatography and HPLC. Fradiamine A was a new compound, but fradiamine B was previously patented as a sweetness enhancer. Their structures were determined by NMR and LC-HRESI-MS/MS analysis. Fradiamines A and B contained two alkyl amines asymmetrically bonded to citrate, a type of structure derived from actinomycetes and other bacteria and rarely observed in siderophores. Fradiamines A and B showed moderate antibiotic activity against Clostridium difficile with IC50 values of 32 and 8 μg ml-1, respectively. |
| Volume | 70(5) |
| Pages | 611-615 |
| Published | 2017-5-1 |
| DOI | 10.1038/ja.2017.26 |
| PII | ja201726 |
| PMID | 28246378 |
| MeSH | Acetates / chemistry Acetates / isolation & purification Acetates / pharmacology* Anti-Bacterial Agents / chemistry Anti-Bacterial Agents / isolation & purification Anti-Bacterial Agents / pharmacology* Chromatography, Liquid Clostridioides difficile / drug effects* Diamines / chemistry Diamines / isolation & purification Diamines / pharmacology* Inhibitory Concentration 50 Magnetic Resonance Spectroscopy Mass Spectrometry Siderophores / chemistry Siderophores / isolation & purification Siderophores / pharmacology* Streptomyces / metabolism* |
| IF | 2.446 |
| Times Cited | 10 |
| Resource | |
| General Microbes | JCM 1386 JCM 1391 JCM 1380 JCM 1292 JCM 1427 JCM 1298 |