論文 - 詳細
RRC ID | 50812 |
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著者 | Takehana Y, Umekita M, Hatano M, Kato C, Sawa R, Igarashi M. |
タイトル | Fradiamine A, a new siderophore from the deep-sea actinomycete Streptomyces fradiae MM456M-mF7. |
ジャーナル | J Antibiot (Tokyo) |
Abstract |
New bioactive substances were identified from several marine actinomycetes strains by LC-HRESI-MS based non-targeted metabolomics. A new siderophore and its derivative, named fradiamines A and B, were isolated from the extract of the deep-sea actinomycetes Streptomyces fradiae MM456M-mF7 by Diaion CHP-20P, Sephadex LH-20 column chromatography and HPLC. Fradiamine A was a new compound, but fradiamine B was previously patented as a sweetness enhancer. Their structures were determined by NMR and LC-HRESI-MS/MS analysis. Fradiamines A and B contained two alkyl amines asymmetrically bonded to citrate, a type of structure derived from actinomycetes and other bacteria and rarely observed in siderophores. Fradiamines A and B showed moderate antibiotic activity against Clostridium difficile with IC50 values of 32 and 8 μg ml-1, respectively. |
巻・号 | 70(5) |
ページ | 611-615 |
公開日 | 2017-5-1 |
DOI | 10.1038/ja.2017.26 |
PII | ja201726 |
PMID | 28246378 |
MeSH | Acetates / chemistry Acetates / isolation & purification Acetates / pharmacology* Anti-Bacterial Agents / chemistry Anti-Bacterial Agents / isolation & purification Anti-Bacterial Agents / pharmacology* Chromatography, Liquid Clostridioides difficile / drug effects* Diamines / chemistry Diamines / isolation & purification Diamines / pharmacology* Inhibitory Concentration 50 Magnetic Resonance Spectroscopy Mass Spectrometry Siderophores / chemistry Siderophores / isolation & purification Siderophores / pharmacology* Streptomyces / metabolism* |
IF | 2.446 |
引用数 | 10 |
リソース情報 | |
一般微生物 | JCM 1386 JCM 1391 JCM 1380 JCM 1292 JCM 1427 JCM 1298 |