RRC ID 50814
著者 Aoki R, Kamikado K, Suda W, Takii H, Mikami Y, Suganuma N, Hattori M, Koga Y.
タイトル A proliferative probiotic Bifidobacterium strain in the gut ameliorates progression of metabolic disorders via microbiota modulation and acetate elevation.
ジャーナル Sci Rep
Abstract The gut microbiota is an important contributor to the worldwide prevalence of metabolic syndrome (MS), which includes obesity and diabetes. The anti-MS effects exerted by Bifidobacterium animalis ssp. lactis GCL2505 (BlaG), a highly proliferative Bifidobacterium strain in the gut, and B. longum ssp. longum JCM1217T (BloJ) were comparatively examined. BlaG treatment reduced visceral fat accumulation and improved glucose tolerance, whereas BloJ had no effect on these parameters. Gut microbial analysis revealed that BlaG exerted stronger effects on the overall bacterial structure of the gut microbiota than BloJ, including enrichment of the genus Bifidobacterium. The levels of acetate and glucagon-like peptide-1 were increased by BlaG treatment in both the gut and plasma, but not by BloJ treatment. Correlation analysis suggested that the elevation of gut acetate levels by BlaG treatment plays a pivotal role in the BlaG-induced anti-MS effects. These findings indicated that BlaG, a highly viable and proliferative probiotic, improves metabolic disorders by modulating gut microbiota, which results in the elevation of SCFAs, especially acetate.
巻・号 7
ページ 43522
公開日 2017-3-2
DOI 10.1038/srep43522
PII srep43522
PMID 28252037
PMC PMC5333160
MeSH Acetates / metabolism* Animals Bifidobacterium / metabolism* Disease Models, Animal Gastrointestinal Microbiome* Glucose / metabolism Glucose Intolerance / metabolism Glucose Intolerance / therapy Male Metabolic Diseases / etiology Metabolic Diseases / metabolism* Metabolic Diseases / therapy Metagenome Metagenomics / methods Mice Probiotics*
IF 3.998
引用数 43
リソース情報
一般微生物 JCM 1217