論文 - 詳細
| RRC ID | 50930 |
|---|---|
| 著者 | Mizuno K, Akimoto N, Kawamura M, Nakase K, Noguchi N, Sato T. |
| タイトル | Involvement of adenosine triphosphate-binding cassette subfamily B member 1 in the augmentation of triacylglycerol excretion by Propionibacterium acnes in differentiated hamster sebocytes. |
| ジャーナル | J Dermatol |
| Abstract |
An onset of acne, a common inflammatory skin disease, is associated with excess sebum production and secretion in sebaceous glands. Because Propionibacterium acnes has been reported to augment intracellular sebum accumulation in sebaceous glands in hamsters, it remains unclear whether P. acnes influences sebum secretion from differentiated sebocytes. Both P. acnes culture media (Acnes73-CM) and formalin-killed P. acnes (F-Acnes73) dose-dependently increased the extracellular levels of triacylglycerol (TG), a major sebum component, and Rhodamine 123, a substrate of adenosine triphosphate-binding cassette (ABC) transporter, from differentiated hamster sebocytes (DHS). In addition, the gene expression of the ABC subfamily B member 1 (ABCB1) was dose-dependently augmented by adding Acnes73-CM and F-Acnes73 into DHS. Furthermore, the F-Acnes73-induced increase of TG excretion was suppressed by PSC833, a selective ABCB1 inhibitor. On the other hand, peptidoglycan (PGN), which is a Toll-like receptor 2 (TLR2) ligand in P. acnes, increased extracellular TG levels, transporter activity and ABCB1 mRNA expression in DHS. The PGN-augmented TG excretion was suppressed by PSC833. Thus, these results provide novel evidence that P. acnes facilitates sebum secretion due to the activation of ABCB1 concomitantly with the increased ABCB1 expression, which may result from the activation of the TLR2 pathway in DHS. Therefore, the ABCB1 inhibitor is likely to become a candidate as a possible therapeutic for the treatment of acne. |
| 巻・号 | 44(12) |
| ページ | 1404-1407 |
| 公開日 | 2017-12-1 |
| DOI | 10.1111/1346-8138.13963 |
| PMID | 28714181 |
| MeSH | ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism* Animals Cells, Cultured Cricetinae Peptidoglycan Propionibacterium acnes / physiology* Sebaceous Glands / metabolism* Sebaceous Glands / microbiology Sebum / metabolism* Triglycerides / metabolism* |
| IF | 3.377 |
| 引用数 | 0 |
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 6473 |