RRC ID |
50
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著者 |
Lin Y, Tsuchihashi T, Matsumura K, Fukuhara M, Ohya Y, Fujii K, Iida M.
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タイトル |
Central cardiovascular action of urotensin II in spontaneously hypertensive rats.
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ジャーナル |
Hypertens Res
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Abstract |
We have previously reported that urotensin II acts on the central nervous system to increase blood pressure in normotensive rats. In the present study, we have determined the central cardiovascular action of urotensin II in spontaneously hypertensive rats (SHR). Intracerebroventricular (ICV) injection of urotensin II elicited a dose-dependent increase in blood pressure in both SHR and normotensive Wistar-Kyoto rats (WKY). The changes in mean arterial pressure induced by ICV urotensin II at doses of 1 and 10 nmol in the WKY were 8 +/- 2 and 23 +/- 3 mmHg, respectively. ICV administration of urotensin II caused significantly greater increases in blood pressure in SHR (16 +/- 3 mmHg at 1 nmol and 35 +/- 3 mmHg at 10 nmol, respectively) compared with those in WKY. Urotensin II (10 nmol) elicited significant and comparable increases in heart rate in SHR (107 +/- 10 bpm) and WKY (101 +/- 21 bpm). Plasma epinephrine concentrations after ICV administration of 10 nmol urotensin II were 203 +/- 58 pmol/ml in SHR and 227 +/- 47 pmol/ml in WKY, which tended to be higher than those in artificial cerebrospinal fluid-injected rats (73+/- 7 and 87 +/- 28 pmol/ml, respectively, p < 0.1). The immunoreactivity of urotensin II receptor GPR 14 was expressed extensively in the glial cells within the brainstem, hypothalamus, and thalamus. These results suggest that central urotensin II may play a role in the pathogenesis of hypertension in SHR. Since GPR 14 was expressed in the glial cells of the brain, urotensin II may act as a neuromodulator to regulate blood pressure.
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巻・号 |
26(10)
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ページ |
839-45
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公開日 |
2003-10-1
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DOI |
10.1291/hypres.26.839
|
PMID |
14621188
|
MeSH |
Animals
Blood Pressure / drug effects*
Brain Stem / metabolism
Heart Rate / drug effects
Hypertension / metabolism
Hypertension / physiopathology*
Immunohistochemistry
Injections, Intraventricular
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Receptors, G-Protein-Coupled / metabolism
Urotensins / pharmacology*
|
IF |
2.941
|
引用数 |
40
|
WOS 分野
|
PERIPHERAL VASCULAR DISEASE
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リソース情報 |
ラット |
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