| RRC ID |
51164
|
| 著者 |
Sugiyama Y, Nara M, Sakanaka M, Gotoh A, Kitakata A, Okuda S, Kurihara S.
|
| タイトル |
Comprehensive analysis of polyamine transport and biosynthesis in the dominant human gut bacteria: Potential presence of novel polyamine metabolism and transport genes.
|
| ジャーナル |
Int J Biochem Cell Biol
|
| Abstract |
Recent studies have reported that polyamines in the colonic lumen might affect animal health and these polyamines are thought to be produced by gut bacteria. In the present study, we measured the concentrations of three polyamines (putrescine, spermidine, and spermine) in cells and culture supernatants of 32 dominant human gut bacterial species in their growing and stationary phases. Combining polyamine concentration analysis in culture supernatant and cells with available genomic information showed that novel polyamine biosynthetic proteins and transporters were present in dominant human gut bacteria. Based on these findings, we suggested strategies for optimizing polyamine concentrations in the human colonic lumen via regulation of genes responsible for polyamine biosynthesis and transport in the dominant human gut bacteria.
|
| 巻・号 |
93
|
| ページ |
52-61
|
| 公開日 |
2017-12-1
|
| DOI |
10.1016/j.biocel.2017.10.015
|
| PII |
S1357-2725(17)30282-0
|
| PMID |
29102547
|
| MeSH |
Bacteria / genetics
Bacteria / metabolism*
Bacterial Proteins / genetics
Bacterial Proteins / metabolism*
Biogenic Polyamines / metabolism*
Carrier Proteins / genetics
Carrier Proteins / metabolism*
Colon / metabolism
Colon / microbiology*
Gastrointestinal Microbiome / physiology*
Humans
|
| IF |
3.673
|
| 引用数 |
12
|
| リソース情報 |
| 一般微生物 |
JCM 5828
JCM 9498
JCM 5827
JCM 5826
JCM 5824
JCM 15633
JCM 13471
JCM 9496
JCM 13345
JCM 13265
JCM 11019
JCM 9497
JCM 5825
JCM 13406
JCM 14655
JCM 6567
JCM 15631
JCM 7790 |
