論文 - 詳細
| RRC ID | 51164 |
|---|---|
| 著者 | Sugiyama Y, Nara M, Sakanaka M, Gotoh A, Kitakata A, Okuda S, Kurihara S. |
| タイトル | Comprehensive analysis of polyamine transport and biosynthesis in the dominant human gut bacteria: Potential presence of novel polyamine metabolism and transport genes. |
| ジャーナル | Int J Biochem Cell Biol |
| Abstract |
Recent studies have reported that polyamines in the colonic lumen might affect animal health and these polyamines are thought to be produced by gut bacteria. In the present study, we measured the concentrations of three polyamines (putrescine, spermidine, and spermine) in cells and culture supernatants of 32 dominant human gut bacterial species in their growing and stationary phases. Combining polyamine concentration analysis in culture supernatant and cells with available genomic information showed that novel polyamine biosynthetic proteins and transporters were present in dominant human gut bacteria. Based on these findings, we suggested strategies for optimizing polyamine concentrations in the human colonic lumen via regulation of genes responsible for polyamine biosynthesis and transport in the dominant human gut bacteria. |
| 巻・号 | 93 |
| ページ | 52-61 |
| 公開日 | 2017-12-1 |
| DOI | 10.1016/j.biocel.2017.10.015 |
| PII | S1357-2725(17)30282-0 |
| PMID | 29102547 |
| MeSH | Bacteria / genetics Bacteria / metabolism* Bacterial Proteins / genetics Bacterial Proteins / metabolism* Biogenic Polyamines / metabolism* Carrier Proteins / genetics Carrier Proteins / metabolism* Colon / metabolism Colon / microbiology* Gastrointestinal Microbiome / physiology* Humans |
| IF | 3.673 |
| 引用数 | 12 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 5828 JCM 9498 JCM 5827 JCM 5826 JCM 5824 JCM 15633 JCM 13471 JCM 9496 JCM 13345 JCM 13265 JCM 11019 JCM 9497 JCM 5825 JCM 13406 JCM 14655 JCM 6567 JCM 15631 JCM 7790 |