RRC ID 51286
著者 Miller AC, Whitebirch AC, Shah AN, Marsden KC, Granato M, O'Brien J, Moens CB.
タイトル A genetic basis for molecular asymmetry at vertebrate electrical synapses.
ジャーナル Elife
Abstract Neural network function is based upon the patterns and types of connections made between neurons. Neuronal synapses are adhesions specialized for communication and they come in two types, chemical and electrical. Communication at chemical synapses occurs via neurotransmitter release whereas electrical synapses utilize gap junctions for direct ionic and metabolic coupling. Electrical synapses are often viewed as symmetrical structures, with the same components making both sides of the gap junction. By contrast, we show that a broad set of electrical synapses in zebrafish, Danio rerio, require two gap-junction-forming Connexins for formation and function. We find that one Connexin functions presynaptically while the other functions postsynaptically in forming the channels. We also show that these synapses are required for the speed and coordination of escape responses. Our data identify a genetic basis for molecular asymmetry at vertebrate electrical synapses and show they are required for appropriate behavioral performance.
巻・号 6
公開日 2017-5-22
DOI 10.7554/eLife.25364
PII e25364
PMID 28530549
PMC PMC5462537
MeSH Animals Connexins / genetics* Connexins / metabolism* Electrical Synapses* Gap Junctions / physiology* Neurons / physiology* Zebrafish
IF 7.08
引用数 8
リソース情報
ゼブラフィッシュ Tol-056