Reference - Detail
| RRC ID | 51362 |
|---|---|
| Author | Chen CH, He CW, Liao CP, Pan CL. |
| Title | A Wnt-planar polarity pathway instructs neurite branching by restricting F-actin assembly through endosomal signaling. |
| Journal | PLoS Genet |
| Abstract |
Spatial arrangement of neurite branching is instructed by both attractive and repulsive cues. Here we show that in C. elegans, the Wnt family of secreted glycoproteins specify neurite branching sites in the PLM mechanosensory neurons. Wnts function through MIG-1/Frizzled and the planar cell polarity protein (PCP) VANG-1/Strabismus/Vangl2 to restrict the formation of F-actin patches, which mark branching sites in nascent neurites. We find that VANG-1 promotes Wnt signaling by facilitating Frizzled endocytosis and genetically acts in a common pathway with arr-1/β-arrestin, whose mutation results in defective PLM branching and F-actin patterns similar to those in the Wnt, mig-1 or vang-1 mutants. On the other hand, the UNC-6/Netrin pathway intersects orthogonally with Wnt-PCP signaling to guide PLM branch growth along the dorsal-ventral axis. Our study provides insights for how attractive and repulsive signals coordinate to sculpt neurite branching patterns, which are critical for circuit connectivity. |
| Volume | 13(4) |
| Pages | e1006720 |
| Published | 2017-4-1 |
| DOI | 10.1371/journal.pgen.1006720 |
| PII | PGENETICS-D-17-00048 |
| PMID | 28384160 |
| PMC | PMC5398721 |
| MeSH | Actins / genetics Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / growth & development Caenorhabditis elegans Proteins / genetics* Cell Polarity / genetics Endocytosis / genetics Frizzled Receptors / genetics* Nerve Tissue Proteins / genetics* Netrins Neurites / metabolism Neurogenesis / genetics* Neurons / metabolism Phosphoproteins / genetics* Wnt Signaling Pathway / genetics beta-Arrestin 1 / genetics* |
| IF | 5.175 |
| Times Cited | 11 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 6 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm1422 |