論文 - 詳細
| RRC ID | 51368 |
|---|---|
| 著者 | Yogev S, Maeder CI, Cooper R, Horowitz M, Hendricks AG, Shen K. |
| タイトル | Local inhibition of microtubule dynamics by dynein is required for neuronal cargo distribution. |
| ジャーナル | Nat Commun |
| Abstract |
Abnormal axonal transport is associated with neuronal disease. We identified a role for DHC-1, the C. elegans dynein heavy chain, in maintaining neuronal cargo distribution. Surprisingly, this does not involve dynein's role as a retrograde motor in cargo transport, hinging instead on its ability to inhibit microtubule (MT) dynamics. Neuronal MTs are highly static, yet the mechanisms and functional significance of this property are not well understood. In disease-mimicking dhc-1 alleles, excessive MT growth and collapse occur at the dendrite tip, resulting in the formation of aberrant MT loops. These unstable MTs act as cargo traps, leading to ectopic accumulations of cargo and reduced availability of cargo at normal locations. Our data suggest that an anchored dynein pool interacts with plus-end-out MTs to stabilize MTs and allow efficient retrograde transport. These results identify functional significance for neuronal MT stability and suggest a mechanism for cellular dysfunction in dynein-linked disease. |
| 巻・号 | 8 |
| ページ | 15063 |
| 公開日 | 2017-4-13 |
| DOI | 10.1038/ncomms15063 |
| PII | ncomms15063 |
| PMID | 28406181 |
| PMC | PMC5399302 |
| MeSH | Animals Animals, Genetically Modified Axonal Transport COS Cells Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Chlorocebus aethiops Cytoplasmic Dyneins / genetics Cytoplasmic Dyneins / metabolism* Dendrites / metabolism Green Fluorescent Proteins / genetics Green Fluorescent Proteins / metabolism Microscopy, Confocal Microtubules / metabolism* Mutation Neurons / metabolism* Time-Lapse Imaging / methods |
| IF | 12.121 |
| 引用数 | 10 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1572 |