Reference - Detail
| RRC ID | 51375 |
|---|---|
| Author | Tang H, Han M. |
| Title | Fatty Acids Regulate Germline Sex Determination through ACS-4-Dependent Myristoylation. |
| Journal | Cell |
| Abstract |
Fat metabolism has been linked to fertility and reproductive adaptation in animals and humans, and environmental sex determination potentially plays a role in the process. To investigate the impact of fatty acids (FA) on sex determination and reproductive development, we examined and observed an impact of FA synthesis and mobilization by lipolysis in somatic tissues on oocyte fate in Caenorhabditis elegans. The subsequent genetic analysis identified ACS-4, an acyl-CoA synthetase and its FA-CoA product, as key germline factors that mediate the role of FA in promoting oocyte fate through protein myristoylation. Further tests indicated that ACS-4-dependent protein myristoylation perceives and translates the FA level into regulatory cues that modulate the activities of MPK-1/MAPK and key factors in the germline sex-determination pathway. These findings, including a similar role of ACS-4 in a male/female species, uncover a likely conserved mechanism by which FA, an environmental factor, regulates sex determination and reproductive development. |
| Volume | 169(3) |
| Pages | 457-469.e13 |
| Published | 2017-4-20 |
| DOI | 10.1016/j.cell.2017.03.049 |
| PII | S0092-8674(17)30411-7 |
| PMID | 28431246 |
| MeSH | Acetate-CoA Ligase / genetics Acetate-CoA Ligase / metabolism* Animals Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Fatty Acids / metabolism* Mutation Myristic Acid / metabolism* Oocytes / metabolism Protein Processing, Post-Translational* Sex Determination Processes* |
| IF | 38.637 |
| Times Cited | 14 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 52 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm3480 tm4063 |