論文 - 詳細
| RRC ID | 51378 |
|---|---|
| 著者 | Meng J, Ma X, Tao H, Jin X, Witvliet D, Mitchell J, Zhu M, Dong MQ, Zhen M, Jin Y, Qi YB. |
| タイトル | Myrf ER-Bound Transcription Factors Drive C. elegans Synaptic Plasticity via Cleavage-Dependent Nuclear Translocation. |
| ジャーナル | Dev Cell |
| Abstract |
Synaptic refinement is a critical step in nervous system maturation, requiring a carefully timed reorganization and refinement of neuronal connections. We have identified myrf-1 and myrf-2, two C. elegans homologs of Myrf family transcription factors, as key regulators of synaptic rewiring. MYRF-1 and its paralog MYRF-2 are functionally redundant specifically in synaptic rewiring. They co-exist in the same protein complex and act cooperatively to regulate synaptic rewiring. We find that the MYRF proteins localize to the ER membrane and that they are cleaved into active N-terminal fragments, which then translocate into the nucleus to drive synaptic rewiring. Overexpression of active forms of MYRF is sufficient to accelerate synaptic rewiring. MYRF-1 and MYRF-2 are the first genes identified to be indispensable for promoting synaptic rewiring in C. elegans. These findings reveal a molecular mechanism underlying synaptic rewiring and developmental circuit plasticity. |
| 巻・号 | 41(2) |
| ページ | 180-194.e7 |
| 公開日 | 2017-4-24 |
| DOI | 10.1016/j.devcel.2017.03.022 |
| PII | S1534-5807(17)30208-3 |
| PMID | 28441531 |
| PMC | PMC5493483 |
| MeSH | Active Transport, Cell Nucleus Animals Caenorhabditis elegans Caenorhabditis elegans Proteins / economics Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism Cell Nucleus / metabolism Endoplasmic Reticulum / metabolism* Membrane Proteins / metabolism Neuronal Plasticity / genetics* Synapses / metabolism* Transcription Factors / metabolism* |
| IF | 10.092 |
| 引用数 | 9 |
| リソース情報 | |
| 線虫 | tm2707 tm3445 |