論文 - 詳細
| RRC ID | 51412 |
|---|---|
| 著者 | Shen Q, Shi H, Tian C, Ghai V, Liu J. |
| タイトル | The C. elegans Spalt-like protein SEM-4 functions through the SoxC transcription factor SEM-2 to promote a proliferative blast cell fate in the postembryonic mesoderm. |
| ジャーナル | Dev Biol |
| Abstract |
Proper development of a multicellular organism relies on well-coordinated regulation of cell fate specification, cell proliferation and cell differentiation. The C. elegans postembryonic mesoderm provides a useful system for uncovering factors involved in these processes and for further dissecting their regulatory relationships. The single Spalt-like zinc finger containing protein SEM-4/SALL is known to be involved in specifying the proliferative sex myoblast (SM) fate. We have found that SEM-4/SALL is sufficient to promote the SM fate and that it does so in a cell autonomous manner. We further showed that SEM-4/SALL acts through the SoxC transcription factor SEM-2 to promote the SM fate. SEM-2 is known to promote the SM fate by inhibiting the expression of two BWM-specifying transcription factors. In light of recent findings in mammals showing that Sall4, one of the mammalian homologs of SEM-4, contributes to pluripotency regulation by inhibiting differentiation, our work suggests that the function of SEM-4/SALL proteins in regulating pluripotency versus differentiation appears to be evolutionarily conserved. |
| 巻・号 | 429(1) |
| ページ | 335-342 |
| 公開日 | 2017-9-1 |
| DOI | 10.1016/j.ydbio.2017.06.011 |
| PII | S0012-1606(17)30310-X |
| PMID | 28614700 |
| PMC | PMC5554739 |
| MeSH | Animals Caenorhabditis elegans / cytology* Caenorhabditis elegans / embryology* Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / metabolism* Cell Differentiation Cell Lineage* Cell Proliferation DNA-Binding Proteins / metabolism* Embryo, Nonmammalian / cytology* Gene Expression Regulation, Developmental Mesoderm / cytology* Models, Biological Mutation / genetics Regulatory Sequences, Nucleic Acid / genetics SOXC Transcription Factors / metabolism* |
| IF | 2.896 |
| 引用数 | 0 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm547 |