論文 - 詳細
| RRC ID | 51432 |
|---|---|
| 著者 | Kratsios P, Kerk SY, Catela C, Liang J, Vidal B, Bayer EA, Feng W, De La Cruz ED, Croci L, Consalez GG, Mizumoto K, Hobert O. |
| タイトル | An intersectional gene regulatory strategy defines subclass diversity of C. elegans motor neurons. |
| ジャーナル | Elife |
| Abstract |
A core principle of nervous system organization is the diversification of neuron classes into subclasses that share large sets of features but differ in select traits. We describe here a molecular mechanism necessary for motor neurons to acquire subclass-specific traits in the nematode Caenorhabditis elegans. Cholinergic motor neuron classes of the ventral nerve cord can be subdivided into subclasses along the anterior-posterior (A-P) axis based on synaptic connectivity patterns and molecular features. The conserved COE-type terminal selector UNC-3 not only controls the expression of traits shared by all members of a neuron class, but is also required for subclass-specific traits expressed along the A-P axis. UNC-3, which is not regionally restricted, requires region-specific cofactors in the form of Hox proteins to co-activate subclass-specific effector genes in post-mitotic motor neurons. This intersectional gene regulatory principle for neuronal subclass diversification may be conserved from nematodes to mice. |
| 巻・号 | 6 |
| 公開日 | 2017-7-5 |
| DOI | 10.7554/eLife.25751 |
| PII | e25751 |
| PMID | 28677525 |
| PMC | PMC5498135 |
| MeSH | Animals Biological Variation, Population Caenorhabditis elegans / embryology* Caenorhabditis elegans Proteins / metabolism Cell Differentiation* Gene Expression Regulation, Developmental* Homeodomain Proteins / metabolism Mice Motor Neurons / physiology* Transcription Factors / metabolism |
| IF | 7.08 |
| リソース情報 | |
| 線虫 | tm4746 |