論文 - 詳細
| RRC ID | 51458 |
|---|---|
| 著者 | Rojo Romanos T, Pladevall-Morera D, Langebeck-Jensen K, Hansen S, Ng L, Pocock R. |
| タイトル | LIN-32/Atonal Controls Oxygen Sensing Neuron Development in Caenorhabditis elegans. |
| ジャーナル | Sci Rep |
| Abstract |
Development of complex nervous systems requires precisely controlled neurogenesis. The generation and specification of neurons occur through the transcriptional and post-transcriptional control of complex regulatory networks. In vertebrates and invertebrates, the proneural basic-helix-loop-helix (bHLH) family of transcription factors has multiple functions in neurogenesis. Here, we identified the LIN-32/Atonal bHLH transcription factor as a key regulator of URXL/R oxygen-sensing neuron development in Caenorhabditis elegans. When LIN-32/Atonal expression is lost, the expression of URX specification and terminal differentiation genes is abrogated. As such, lin-32 mutant animals are unable to respond to increases in environmental oxygen. The URX neurons are generated from a branch of the cell lineage that also produces the CEPDL/R and URADL/R neurons. We found development of these neurons is also defective, suggesting that LIN-32/Atonal regulates neuronal development of the entire lineage. Finally, our results show that aspects of URX neuronal fate are partially restored in lin-32 mutant animals when the apoptosis pathway is inhibited. This suggests that, as in other organisms, LIN-32/Atonal regulates neuronal apoptosis. |
| 巻・号 | 7(1) |
| ページ | 7294 |
| 公開日 | 2017-8-4 |
| DOI | 10.1038/s41598-017-07876-4 |
| PII | 10.1038/s41598-017-07876-4 |
| PMID | 28779171 |
| PMC | PMC5544745 |
| MeSH | Animals Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Gene Expression Genes, Reporter Mutation Neurogenesis* Neurons / metabolism* Oxygen / metabolism* Transcription Factors / genetics Transcription Factors / metabolism* |
| IF | 3.998 |
| 引用数 | 1 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1446 tm1768 |