論文 - 詳細
| RRC ID | 51480 |
|---|---|
| 著者 | Ohno H, Sakai N, Adachi T, Iino Y. |
| タイトル | Dynamics of Presynaptic Diacylglycerol in a Sensory Neuron Encode Differences between Past and Current Stimulus Intensity. |
| ジャーナル | Cell Rep |
| Abstract |
Memorizing the intensity of sensory stimuli enables animals to successfully deal with changing environmental conditions and contributes to cognitive functions such as auditory and visual working memory. However, how nervous systems process past and current stimulus intensity is largely unknown at the molecular level. Here, we employ in vivo diacylglycerol (DAG) imaging in the ASER taste neuron of Caenorhabditis elegans and demonstrate that associative learning between ambient salt concentrations and food can be explained by changes in presynaptic DAG. The abundance of DAG is regulated in response to external salt concentration changes via sensory transduction in ASER and can encode differences between past and current salt concentrations. The DAG dynamics are modulated downstream of the synaptic insulin/phosphatidylinositol 3-kinase (PI3K)/Akt pathway, which regulates the behavioral plasticity induced by starvation. These results provide insights into how a single neuron stores past input intensity and generates appropriate behavioral responses. |
| 巻・号 | 20(10) |
| ページ | 2294-2303 |
| 公開日 | 2017-9-5 |
| DOI | 10.1016/j.celrep.2017.08.038 |
| PII | S2211-1247(17)31145-2 |
| PMID | 28877465 |
| MeSH | Animals Caenorhabditis elegans / metabolism* Caenorhabditis elegans / physiology Caenorhabditis elegans Proteins / metabolism* Chemotaxis / genetics Chemotaxis / physiology Diglycerides / metabolism Insulin / metabolism Memory / physiology Phosphatidylinositol 3-Kinases / metabolism Proto-Oncogene Proteins c-akt / metabolism |
| IF | 8.109 |
| 引用数 | 3 |
| リソース情報 | |
| 線虫 | tm718 |