論文 - 詳細
| RRC ID | 51506 |
|---|---|
| 著者 | Chen J, Ou Y, Li Y, Hu S, Shao LW, Liu Y. |
| タイトル | Metformin extends C. elegans lifespan through lysosomal pathway. |
| ジャーナル | Elife |
| Abstract |
Metformin, a widely used first-line drug for treatment of type 2 diabetes (T2D), has been shown to extend lifespan and delay the onset of age-related diseases. However, its primary locus of action remains unclear. Using a pure in vitro reconstitution system, we demonstrate that metformin acts through the v-ATPase-Ragulator lysosomal pathway to coordinate mTORC1 and AMPK, two hubs governing metabolic programs. We further show in Caenorhabditis elegans that both v-ATPase-mediated TORC1 inhibition and v-ATPase-AXIN/LKB1-mediated AMPK activation contribute to the lifespan extension effect of metformin. Elucidating the molecular mechanism of metformin regulated healthspan extension will boost its therapeutic application in the treatment of human aging and age-related diseases. |
| 巻・号 | 6 |
| 公開日 | 2017-10-13 |
| DOI | 10.7554/eLife.31268 |
| PII | 31268 |
| PMID | 29027899 |
| PMC | PMC5685485 |
| MeSH | AMP-Activated Protein Kinases / metabolism Animals Caenorhabditis elegans / drug effects* Caenorhabditis elegans / physiology* Hypoglycemic Agents / metabolism* Longevity / drug effects Lysosomes / metabolism* Mechanistic Target of Rapamycin Complex 1 / metabolism Metformin / metabolism* |
| IF | 7.08 |
| 引用数 | 17 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 60 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2339 tm2367 |