論文 - 詳細
| RRC ID | 51522 |
|---|---|
| 著者 | Clark JF, Meade M, Ranepura G, Hall DH, Savage-Dunn C. |
| タイトル | Caenorhabditis elegans DBL-1/BMP Regulates Lipid Accumulation via Interaction with Insulin Signaling. |
| ジャーナル | G3 (Bethesda) |
| Abstract |
Metabolic homeostasis is coordinately controlled by diverse inputs. Understanding these regulatory networks is vital to combating metabolic disorders. The nematode Caenorhabditis elegans has emerged as a powerful, genetically tractable model system for the discovery of lipid regulatory mechanisms. Here we introduce DBL-1, the C. elegans homolog of bone morphogenetic protein 2/4 (BMP2/4), as a significant regulator of lipid homeostasis. We used neutral lipid staining and a lipid droplet marker to demonstrate that both increases and decreases in DBL-1/BMP signaling result in reduced lipid stores and lipid droplet count. We find that lipid droplet size, however, correlates positively with the level of DBL-1/BMP signaling. Regulation of lipid accumulation in the intestine occurs through non-cell-autonomous signaling, since expression of SMA-3, a Smad signal transducer, in the epidermis (hypodermis) is sufficient to rescue the loss of lipid accumulation. Finally, genetic evidence indicates that DBL-1/BMP functions upstream of Insulin/IGF-1 Signaling in lipid metabolism. We conclude that BMP signaling regulates lipid metabolism in C. elegans through interorgan signaling to the Insulin pathway, shedding light on a less well-studied regulatory mechanism for metabolic homeostasis. |
| 巻・号 | 8(1) |
| ページ | 343-351 |
| 公開日 | 2018-1-4 |
| DOI | 10.1534/g3.117.300416 |
| PII | g3.117.300416 |
| PMID | 29162682 |
| PMC | PMC5765361 |
| MeSH | Animals Caenorhabditis elegans / genetics* Caenorhabditis elegans / growth & development Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism Gene Expression Regulation, Developmental Gene Regulatory Networks Homeostasis Insulin / genetics Insulin / metabolism* Insulin-Like Growth Factor I / genetics* Insulin-Like Growth Factor I / metabolism Lipid Droplets / metabolism Lipid Metabolism / genetics* Neuropeptides / genetics* Neuropeptides / metabolism Organ Specificity Signal Transduction Transforming Growth Factor beta / genetics* Transforming Growth Factor beta / metabolism |
| IF | 2.781 |
| 引用数 | 7 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 26 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm331 |