論文 - 詳細
| RRC ID | 51523 |
|---|---|
| 著者 | Stern S, Kirst C, Bargmann CI. |
| タイトル | Neuromodulatory Control of Long-Term Behavioral Patterns and Individuality across Development. |
| ジャーナル | Cell |
| Abstract |
Animals generate complex patterns of behavior across development that may be shared or unique to individuals. Here, we examine the contributions of developmental programs and individual variation to behavior by monitoring single Caenorhabditis elegans nematodes over their complete developmental trajectories and quantifying their behavior at high spatiotemporal resolution. These measurements reveal reproducible trajectories of spontaneous foraging behaviors that are stereotyped within and between developmental stages. Dopamine, serotonin, the neuropeptide receptor NPR-1, and the TGF-β peptide DAF-7 each have stage-specific effects on behavioral trajectories, implying the existence of a modular temporal program controlled by neuromodulators. In addition, a fraction of individuals within isogenic populations raised in controlled environments have consistent, non-genetic behavioral biases that persist across development. Several neuromodulatory systems increase or decrease the degree of non-genetic individuality to shape sustained patterns of behavior across the population. |
| 巻・号 | 171(7) |
| ページ | 1649-1662.e10 |
| 公開日 | 2017-12-14 |
| DOI | 10.1016/j.cell.2017.10.041 |
| PII | S0092-8674(17)31267-9 |
| PMID | 29198526 |
| MeSH | Animals Behavior, Animal Biological Variation, Individual* Caenorhabditis elegans / growth & development* Caenorhabditis elegans / physiology* Dopamine / metabolism Gene Expression Regulation Larva / physiology Neuroimaging / instrumentation Neuroimaging / methods Neuropeptides / genetics Neuropeptides / metabolism* Receptors, Serotonin / genetics Receptors, Serotonin / metabolism |
| IF | 38.637 |
| 引用数 | 21 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 73 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1325 tm2647 |