論文 - 詳細
| RRC ID | 51566 |
|---|---|
| 著者 | Muto A, Lal P, Ailani D, Abe G, Itoh M, Kawakami K. |
| タイトル | Activation of the hypothalamic feeding centre upon visual prey detection. |
| ジャーナル | Nat Commun |
| Abstract |
The visual system plays a major role in food/prey recognition in diurnal animals, and food intake is regulated by the hypothalamus. However, whether and how visual information about prey is conveyed to the hypothalamic feeding centre is largely unknown. Here we perform real-time imaging of neuronal activity in freely behaving or constrained zebrafish larvae and demonstrate that prey or prey-like visual stimuli activate the hypothalamic feeding centre. Furthermore, we identify prey detector neurons in the pretectal area that project to the hypothalamic feeding centre. Ablation of the pretectum completely abolishes prey capture behaviour and neurotoxin expression in the hypothalamic area also reduces feeding. Taken together, these results suggest that the pretecto-hypothalamic pathway plays a crucial role in conveying visual information to the feeding centre. Thus, this pathway possibly converts visual food detection into feeding motivation in zebrafish. |
| 巻・号 | 8 |
| ページ | 15029 |
| 公開日 | 2017-4-20 |
| DOI | 10.1038/ncomms15029 |
| PII | ncomms15029 |
| PMID | 28425439 |
| PMC | PMC5411483 |
| MeSH | Animals Animals, Genetically Modified Calcium / metabolism Feeding Behavior / physiology* Hypothalamus / physiology* Larva / genetics Larva / physiology Microscopy, Confocal Neurons / physiology Predatory Behavior / physiology* Visual Pathways / physiology* Zebrafish |
| IF | 12.121 |
| 引用数 | 32 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 19 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | UAShspzGCaMP6s gSAIzGFFM119B hspGFFDMC76A UAS:zBoTxBLCGFP42A |