論文 - 詳細
| RRC ID | 51570 |
|---|---|
| 著者 | Lopez-Baez JC, Simpson DJ, LLeras Forero L, Zeng Z, Brunsdon H, Salzano A, Brombin A, Wyatt C, Rybski W, Huitema LFA, Dale RM, Kawakami K, Englert C, Chandra T, Schulte-Merker S, Hastie ND, Patton EE. |
| タイトル | Wilms Tumor 1b defines a wound-specific sheath cell subpopulation associated with notochord repair. |
| ジャーナル | Elife |
| Abstract |
Regenerative therapy for degenerative spine disorders requires the identification of cells that can slow down and possibly reverse degenerative processes. Here, we identify an unanticipated wound-specific notochord sheath cell subpopulation that expresses Wilms Tumor (WT) 1b following injury in zebrafish. We show that localized damage leads to Wt1b expression in sheath cells, and that wt1b+cells migrate into the wound to form a stopper-like structure, likely to maintain structural integrity. Wt1b+sheath cells are distinct in expressing cartilage and vacuolar genes, and in repressing a Wt1b-p53 transcriptional programme. At the wound, wt1b+and entpd5+ cells constitute separate, tightly-associated subpopulations. Surprisingly, wt1b expression at the site of injury is maintained even into adult stages in developing vertebrae, which form in an untypical manner via a cartilage intermediate. Given that notochord cells are retained in adult intervertebral discs, the identification of novel subpopulations may have important implications for regenerative spine disorder treatments. |
| 巻・号 | 7 |
| 公開日 | 2018-2-6 |
| DOI | 10.7554/eLife.30657 |
| PII | 30657 |
| PMID | 29405914 |
| PMC | PMC5811212 |
| MeSH | Animals Cell Movement Nerve Regeneration* Neuroglia / chemistry* Neuroglia / physiology* Notochord / injuries* WT1 Proteins / analysis* Wound Healing* Zebrafish |
| IF | 7.08 |
| 引用数 | 10 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 21 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | |