論文 - 詳細
| RRC ID | 51735 |
|---|---|
| 著者 | Sasaki S, Kanzaki M, Kaneko T. |
| タイトル | Calcium influx through TRP channels induced by short-lived reactive species in plasma-irradiated solution. |
| ジャーナル | Sci Rep |
| Abstract |
Non-equilibrium helium atmospheric-pressure plasma (He-APP), which allows for a strong non-equilibrium chemical reaction of O2 and N2 in ambient air, uniquely produces multiple extremely reactive products, such as reactive oxygen species (ROS), in plasma-irradiated solution. We herein show that relatively short-lived unclassified reactive species (i.e., deactivated within approximately 10 min) generated by the He-APP irradiation can trigger physiologically relevant Ca(2+) influx through ruthenium red- and SKF 96365-sensitive Ca(2+)-permeable channel(s), possibly transient receptor potential channel family member(s). Our results provide novel insight into understanding of the interactions between cells and plasmas and the mechanism by which cells detect plasma-induced chemically reactive species, in addition to facilitating development of plasma applications in medicine. |
| 巻・号 | 6 |
| ページ | 25728 |
| 公開日 | 2016-5-12 |
| DOI | 10.1038/srep25728 |
| PII | srep25728 |
| PMID | 27169489 |
| PMC | PMC4864414 |
| MeSH | 3T3-L1 Cells Animals Atmospheric Pressure Calcium / metabolism* Glucose / pharmacology Helium / pharmacology Hydrogen Peroxide / metabolism Hydroxyl Radical / metabolism Imidazoles / metabolism Mannitol / pharmacology Mice Plasma Gases / pharmacology* Reactive Oxygen Species / metabolism* Ruthenium Red / metabolism Single-Cell Analysis Solutions Time Factors Time-Lapse Imaging Transient Receptor Potential Channels / metabolism* |
| IF | 3.998 |
| 引用数 | 19 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 8 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MCF7(RCB1904) |