論文 - 詳細
RRC ID | 51743 |
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著者 | Zaitsu Y, Iwatake M, Sato K, Tsukuba T. |
タイトル | Lipid droplets affect elimination of Porphyromonas gingivalis in HepG2 cells by altering the autophagy-lysosome system. |
ジャーナル | Microbes Infect |
Abstract |
Recent studies have shown that infection with Porphyromonas gingivalis, a major periodontal pathogen, hastens the progression of non-alcoholic fatty liver disease (NAFLD). However, the intracellular fate of P. gingivalis in hepatocytes remains unknown. Here, using oleic-acid-induced HepG2 cells as an in vitro model for NAFLD, we found that lipid droplets increased the existence of P. gingivalis in the cells at an early phase of infection. Confocal microscopic analysis revealed that lipid droplets affected the formation of autolysosomes in infected cells. Thus, lipid droplets affect the elimination of P. gingivalis in HepG2 cells by altering the autophagy-lysosome system. |
巻・号 | 18(9) |
ページ | 565-71 |
公開日 | 2016-9-1 |
DOI | 10.1016/j.micinf.2016.05.004 |
PII | S1286-4579(16)30065-X |
PMID | 27237960 |
MeSH | Autophagy* Hep G2 Cells Hepatocytes / cytology Hepatocytes / metabolism Hepatocytes / microbiology* Hepatocytes / physiology* Humans Lipid Droplets / metabolism* Lysosomes / metabolism* Microscopy, Confocal Porphyromonas gingivalis / physiology* |
IF | 2.373 |
引用数 | 2 |
リソース情報 | |
ヒト・動物細胞 | Hep G2(RCB1886) |