RRC ID 51743
Author Zaitsu Y, Iwatake M, Sato K, Tsukuba T.
Title Lipid droplets affect elimination of Porphyromonas gingivalis in HepG2 cells by altering the autophagy-lysosome system.
Journal Microbes Infect
Abstract Recent studies have shown that infection with Porphyromonas gingivalis, a major periodontal pathogen, hastens the progression of non-alcoholic fatty liver disease (NAFLD). However, the intracellular fate of P. gingivalis in hepatocytes remains unknown. Here, using oleic-acid-induced HepG2 cells as an in vitro model for NAFLD, we found that lipid droplets increased the existence of P. gingivalis in the cells at an early phase of infection. Confocal microscopic analysis revealed that lipid droplets affected the formation of autolysosomes in infected cells. Thus, lipid droplets affect the elimination of P. gingivalis in HepG2 cells by altering the autophagy-lysosome system.
Volume 18(9)
Pages 565-71
Published 2016-9-1
DOI 10.1016/j.micinf.2016.05.004
PII S1286-4579(16)30065-X
PMID 27237960
MeSH Autophagy* Hep G2 Cells Hepatocytes / cytology Hepatocytes / metabolism Hepatocytes / microbiology* Hepatocytes / physiology* Humans Lipid Droplets / metabolism* Lysosomes / metabolism* Microscopy, Confocal Porphyromonas gingivalis / physiology*
IF 2.373
Times Cited 2
Resource
Human and Animal Cells Hep G2(RCB1886)