RRC ID 51889
Author Liu W, Al-Oweini R, Meadows K, Bassil BS, Lin Z, Christian JH, Dalal NS, Bossoh AM, Mbomekallé IM, de Oliveira P, Iqbal J, Kortz U.
Title CrIII-Substituted Heteropoly-16-Tungstates [CrIII2(B-β-XIVW8O31)2]14- (X = Si, Ge): Magnetic, Biological, and Electrochemical Studies.
Journal Inorg Chem
Abstract The dichromium(III)-containing heteropoly-16-tungstates [CrIII2(B-β-SiIVW8O31)2]14- (1) and [CrIII2(B-β-GeIVW8O31)2]14- (2) were prepared via a one-pot reaction of the composing elements in aqueous, basic medium. Polyanions 1 and 2 represent the first examples of CrIII-containing heteropolytungstates comprising the octatungstate unit {XW8O31} (X = Si, Ge). Magnetic studies demonstrated that, in the solid state, the two polyanions exhibit a weak antiferromagnetic interaction between the two CrIII centers with J = -3.5 ± 0.5 cm-1, with no long-range ordering down to 1.8 K. The ground-state spin of polyanions 1 and 2 was thus deduced to be 0, but the detection of a complex set of EPR signals implies that there are thermally accessible excited states containing unpaired spins resulting from the two S = 3/2 CrIII ions. A comprehensive electrochemistry study on 1 and 2 in solution was performed, and biological tests showed that both polyanions display significant antidiabetic and anticancer activities.
Volume 55(21)
Pages 10936-10946
Published 2016-11-7
DOI 10.1021/acs.inorgchem.6b01458
PMID 27768287
MeSH Animals Antineoplastic Agents / chemistry* Antineoplastic Agents / pharmacology Cell Line, Tumor Cell Survival / drug effects Chlorocebus aethiops Chromium / chemistry* Chromium / pharmacology Crystallography, X-Ray Diabetes Mellitus / drug therapy Electrochemical Techniques Electron Spin Resonance Spectroscopy Glucosidases / antagonists & inhibitors Humans Hypoglycemic Agents / chemistry* Hypoglycemic Agents / pharmacology Models, Molecular Neoplasms / drug therapy Tungsten Compounds / chemistry* Tungsten Compounds / pharmacology Vero Cells
IF 4.85
Times Cited 8
Human and Animal Cells Vero(RCB0001)