| RRC ID |
51889
|
| 著者 |
Liu W, Al-Oweini R, Meadows K, Bassil BS, Lin Z, Christian JH, Dalal NS, Bossoh AM, Mbomekallé IM, de Oliveira P, Iqbal J, Kortz U.
|
| タイトル |
CrIII-Substituted Heteropoly-16-Tungstates [CrIII2(B-β-XIVW8O31)2]14- (X = Si, Ge): Magnetic, Biological, and Electrochemical Studies.
|
| ジャーナル |
Inorg Chem
|
| Abstract |
The dichromium(III)-containing heteropoly-16-tungstates [CrIII2(B-β-SiIVW8O31)2]14- (1) and [CrIII2(B-β-GeIVW8O31)2]14- (2) were prepared via a one-pot reaction of the composing elements in aqueous, basic medium. Polyanions 1 and 2 represent the first examples of CrIII-containing heteropolytungstates comprising the octatungstate unit {XW8O31} (X = Si, Ge). Magnetic studies demonstrated that, in the solid state, the two polyanions exhibit a weak antiferromagnetic interaction between the two CrIII centers with J = -3.5 ± 0.5 cm-1, with no long-range ordering down to 1.8 K. The ground-state spin of polyanions 1 and 2 was thus deduced to be 0, but the detection of a complex set of EPR signals implies that there are thermally accessible excited states containing unpaired spins resulting from the two S = 3/2 CrIII ions. A comprehensive electrochemistry study on 1 and 2 in solution was performed, and biological tests showed that both polyanions display significant antidiabetic and anticancer activities.
|
| 巻・号 |
55(21)
|
| ページ |
10936-10946
|
| 公開日 |
2016-11-7
|
| DOI |
10.1021/acs.inorgchem.6b01458
|
| PMID |
27768287
|
| MeSH |
Animals
Antineoplastic Agents / chemistry*
Antineoplastic Agents / pharmacology
Cell Line, Tumor
Cell Survival / drug effects
Chlorocebus aethiops
Chromium / chemistry*
Chromium / pharmacology
Crystallography, X-Ray
Diabetes Mellitus / drug therapy
Electrochemical Techniques
Electron Spin Resonance Spectroscopy
Glucosidases / antagonists & inhibitors
Humans
Hypoglycemic Agents / chemistry*
Hypoglycemic Agents / pharmacology
Models, Molecular
Neoplasms / drug therapy
Tungsten Compounds / chemistry*
Tungsten Compounds / pharmacology
Vero Cells
|
| IF |
4.825
|
| 引用数 |
8
|
| リソース情報 |
| ヒト・動物細胞 |
Vero(RCB0001) |
