| RRC ID |
52066
|
| 著者 |
Nguyen NT, Nguyen MT, Nguyen HX, Dang PH, Dibwe DF, Esumi H, Awale S.
|
| タイトル |
Constituents of the Rhizomes of Boesenbergia pandurata and Their Antiausterity Activities against the PANC-1 Human Pancreatic Cancer Line.
|
| ジャーナル |
J Nat Prod
|
| Abstract |
Human pancreatic cancer cell lines have a remarkable tolerance to nutrition starvation, which enables them to survive under a tumor microenvironment. The search for agents that preferentially inhibit the survival of cancer cells under low nutrient conditions represents a novel antiausterity strategy in anticancer drug discovery. In this investigation, a methanol extract of the rhizomes of Boesenbergia pandurata showed potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrient-deprived conditions, with a PC50 value of 6.6 μg/mL. Phytochemical investigation of this extract led to the isolation of 15 compounds, including eight new cyclohexene chalcones (1-8). The structures of the new compounds were elucidated by NMR spectroscopic data analysis. Among the isolated compounds obtained, isopanduratin A1 (14) and nicolaioidesin C (15) exhibited potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition-deprived conditions, with PC50 values of 1.0 and 0.84 μM, respectively.
|
| 巻・号 |
80(1)
|
| ページ |
141-148
|
| 公開日 |
2017-1-27
|
| DOI |
10.1021/acs.jnatprod.6b00784
|
| PMID |
28099006
|
| MeSH |
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology
Cell Line, Tumor
Chalcone / chemistry
Chalcone / isolation & purification*
Chalcone / pharmacology*
Chalcones / chemistry*
Chalcones / isolation & purification
Chalcones / pharmacology
Cyclohexanes / chemistry
Cyclohexanes / isolation & purification*
Cyclohexanes / pharmacology*
Drug Screening Assays, Antitumor
Humans
Molecular Structure
Pancreatic Neoplasms / drug therapy*
Plant Extracts / chemistry*
Rhizome / chemistry*
Zingiberaceae / chemistry*
|
| IF |
3.885
|
| 引用数 |
23
|
| リソース情報 |
| ヒト・動物細胞 |
PANC-1(RCB2095) |
