論文 - 詳細
| RRC ID | 52066 |
|---|---|
| 著者 | Nguyen NT, Nguyen MT, Nguyen HX, Dang PH, Dibwe DF, Esumi H, Awale S. |
| タイトル | Constituents of the Rhizomes of Boesenbergia pandurata and Their Antiausterity Activities against the PANC-1 Human Pancreatic Cancer Line. |
| ジャーナル | J Nat Prod |
| Abstract |
Human pancreatic cancer cell lines have a remarkable tolerance to nutrition starvation, which enables them to survive under a tumor microenvironment. The search for agents that preferentially inhibit the survival of cancer cells under low nutrient conditions represents a novel antiausterity strategy in anticancer drug discovery. In this investigation, a methanol extract of the rhizomes of Boesenbergia pandurata showed potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrient-deprived conditions, with a PC50 value of 6.6 μg/mL. Phytochemical investigation of this extract led to the isolation of 15 compounds, including eight new cyclohexene chalcones (1-8). The structures of the new compounds were elucidated by NMR spectroscopic data analysis. Among the isolated compounds obtained, isopanduratin A1 (14) and nicolaioidesin C (15) exhibited potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition-deprived conditions, with PC50 values of 1.0 and 0.84 μM, respectively. |
| 巻・号 | 80(1) |
| ページ | 141-148 |
| 公開日 | 2017-1-27 |
| DOI | 10.1021/acs.jnatprod.6b00784 |
| PMID | 28099006 |
| MeSH | Antineoplastic Agents, Phytogenic / chemistry Antineoplastic Agents, Phytogenic / isolation & purification* Antineoplastic Agents, Phytogenic / pharmacology Cell Line, Tumor Chalcone / chemistry Chalcone / isolation & purification* Chalcone / pharmacology* Chalcones / chemistry* Chalcones / isolation & purification Chalcones / pharmacology Cyclohexanes / chemistry Cyclohexanes / isolation & purification* Cyclohexanes / pharmacology* Drug Screening Assays, Antitumor Humans Molecular Structure Pancreatic Neoplasms / drug therapy* Plant Extracts / chemistry* Rhizome / chemistry* Zingiberaceae / chemistry* |
| IF | 3.885 |
| 引用数 | 23 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | PANC-1(RCB2095) |