| RRC ID |
52081
|
| 著者 |
Kobayashi D, Kakinouchi K, Nagae T, Nagai T, Shimura K, Hazama A.
|
| タイトル |
Cesium reversibly suppresses HeLa cell proliferation by inhibiting cellular metabolism.
|
| ジャーナル |
FEBS Lett
|
| Abstract |
The aim of the present study was to investigate the influence of Cs+ on cultured human cells. We find that HeLa cell growth is suppressed by the addition of 10 mm CsCl into the culture media. In the Cs+ -treated cells, the intracellular Cs+ and K+ concentrations are increased and decreased, respectively. This leads to a decrease in activity of the glycolytic enzyme pyruvate kinase, which uses K+ as a cofactor. Cs+ -treated cells show an intracellular pH shift towards alkalization. Based on these results, CsCl presumably suppresses HeLa cell proliferation by inducing an intracellular cation imbalance that affects cell metabolism. Our findings may have implications for the use of Cs+ in cancer therapy.
|
| 巻・号 |
591(5)
|
| ページ |
718-727
|
| 公開日 |
2017-3-1
|
| DOI |
10.1002/1873-3468.12579
|
| PMID |
28134446
|
| MeSH |
Cations, Monovalent
Cell Cycle / drug effects*
Cell Proliferation / drug effects*
Cell Survival / drug effects
Cesium / metabolism
Cesium / pharmacology*
Chlorides / pharmacology*
Culture Media / chemistry
Glycolysis / drug effects*
HeLa Cells
Humans
Hydrogen-Ion Concentration
Potassium / metabolism
Pyruvate Kinase / antagonists & inhibitors*
Pyruvate Kinase / metabolism
|
| IF |
3.057
|
| 引用数 |
3
|
| リソース情報 |
| ヒト・動物細胞 |
HeLa/Fucci(RCB2812) |
