RRC ID 52124
著者 Zhang J, Hiromoto S, Yamazaki T, Huang H, Jia G, Li H, Yuan G.
タイトル Macrophage phagocytosis of biomedical Mg alloy degradation products prepared by electrochemical method.
ジャーナル Mater Sci Eng C Mater Biol Appl
Abstract Biomedical Mg alloy is promising for its widespread use clinically. In vitro and in vivo studies showed that the degradation products of biomedical Mg alloy were composed of O, P, Ca, Mg and other alloying elements. However, little is known about the metabolism of the degradation products. In this study, the in vitro macrophage phagocytosis of the degradation products of a biomedical Mg-Nd-Zn-Zr alloy was directly observed. This result affirms the necessity to investigate the long-term fate of Mg alloy degradation products in physiological environments. Besides, an electrochemical method was proposed to prepare enough amount of degradation products in vitro efficiently.
巻・号 75
ページ 1178-1183
公開日 2017-6-1
DOI 10.1016/j.msec.2017.02.126
PII S0928-4931(16)31266-8
PMID 28415404
MeSH Alloys / chemistry Alloys / pharmacokinetics Alloys / pharmacology Animals Electrochemical Techniques* Macrophages / metabolism* Magnesium* / chemistry Magnesium* / pharmacokinetics Magnesium* / pharmacology Mice Phagocytosis / drug effects* RAW 264.7 Cells
IF 5.88
引用数 8
リソース情報
ヒト・動物細胞 RAW 264(RCB0535)