論文 - 詳細
| RRC ID | 52317 |
|---|---|
| 著者 | Rodriguez R, Yoshimura K, Shibata Y, Miyamoto Y, Tanaka R, Uyama R, Sasa K, Suzuki D, Miyazaki T, Kamijo R. |
| タイトル | Nanoindentation time-dependent deformation/recovery suggestive of methylglyoxal induced glycation in calcified nodules. |
| ジャーナル | Nanomedicine |
| Abstract |
Although empirical findings have indicated increase in bone fracture risk in type 2 diabetes patients, that has yet to be proven by results obtained at the material level. Here, we report evidence showing nanoscale time-dependent deformation/recovery of in vitro calcified nodules mimicking bone turnover in type 2 diabetes in respect to methylglyoxal (MG)-induced glycation. Nanoindentation test results revealed that calcified nodules cultured with MG did not show adequate dimensional recovery, despite a large creep rate during constant load indentation testing. This lesser recovery is likely based on the linear matrix polymerization network formed by advanced glycation end products (AGEs) as a secondary product of MG. Since elevated serum MG and abnormal bone turnover related to the amount of AGEs are observed in cases of type 2 diabetes, this time-dependent behavior may be one of the factors of the bone fracture mechanism at the material level in affected patients. |
| 巻・号 | 13(8) |
| ページ | 2545-2553 |
| 公開日 | 2017-11-1 |
| DOI | 10.1016/j.nano.2017.07.003 |
| PII | S1549-9634(17)30133-8 |
| PMID | 28754466 |
| MeSH | Bone and Bones / metabolism Bone and Bones / pathology Calcinosis / metabolism* Calcinosis / pathology Cell Line Cell Proliferation Diabetes Mellitus, Type 2 / metabolism* Diabetes Mellitus, Type 2 / pathology Glycation End Products, Advanced / metabolism* Humans Osteoblasts / cytology Osteoblasts / metabolism* Osteoblasts / pathology Pyruvaldehyde / metabolism* |
| IF | 4.3 |
| 引用数 | 2 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MC3T3-E1(RCB1126) |