論文 - 詳細
| RRC ID | 52342 |
|---|---|
| 著者 | Xu Z, Huo J, Ding X, Yang M, Li L, Dai J, Hosoe K, Kubo H, Mori M, Higuchi K, Sawashita J. |
| タイトル | Coenzyme Q10 Improves Lipid Metabolism and Ameliorates Obesity by Regulating CaMKII-Mediated PDE4 Inhibition. |
| ジャーナル | Sci Rep |
| Abstract |
Our recent studies revealed that supplementation with the reduced form of coenzyme Q10 (CoQ10H2) inhibits oxidative stress and slows the process of aging in senescence-accelerated mice. CoQ10H2 inhibits adipocyte differentiation and regulates lipid metabolism. In the present study, we show that dietary supplementation with CoQ10H2 significantly reduced white adipose tissue content and improved the function of brown adipose tissue by regulating expression of lipid metabolism-related factors in KKAy mice, a model of obesity and type 2 diabetes. In the liver, CoQ10H2 reduced cytoplasmic Ca2+ levels and consequently inhibited the phosphorylation of CaMKII. CoQ10H2 also regulated the activity of the transcription factor C-FOS and inhibited gene expression of PDE4, a cAMP-degrading enzyme, via the CaMKII-MEK1/2-ERK1/2 signaling pathway, thereby increasing intracellular cAMP. This increased cAMP activated AMPK, enhanced oxidative decomposition of lipids, and inhibited de novo synthesis of fatty acids, inhibiting the development and progression of obesity and type 2 diabetes. These results suggest that CoQ10H2 supplementation may be useful as a treatment for metabolic disorders associated with obesity. |
| 巻・号 | 7(1) |
| ページ | 8253 |
| 公開日 | 2017-8-15 |
| DOI | 10.1038/s41598-017-08899-7 |
| PII | 10.1038/s41598-017-08899-7 |
| PMID | 28811612 |
| PMC | PMC5557856 |
| MeSH | Adipocytes / drug effects Adipocytes / metabolism Adipose Tissue, Brown / drug effects Adipose Tissue, Brown / metabolism Animals Body Weight / drug effects Calcium Signaling / drug effects Calcium-Calmodulin-Dependent Protein Kinase Type 2 / metabolism* Cyclic Nucleotide Phosphodiesterases, Type 4 / metabolism* Disease Models, Animal Gene Expression Regulation / drug effects Insulin Resistance Lipid Metabolism* / drug effects Liver / drug effects Liver / metabolism Metabolic Syndrome / drug therapy Metabolic Syndrome / metabolism Mice Obesity / drug therapy Obesity / genetics Obesity / metabolism* Phosphodiesterase 4 Inhibitors / pharmacology Sarcoplasmic Reticulum Calcium-Transporting ATPases / genetics Sarcoplasmic Reticulum Calcium-Transporting ATPases / metabolism Ubiquinone / analogs & derivatives* Ubiquinone / metabolism Ubiquinone / pharmacology |
| IF | 3.998 |
| 引用数 | 22 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | Hep G2(RCB1886) |