論文 - 詳細
RRC ID | 52530 |
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著者 | Manse Y, Ninomiya K, Nishi R, Hashimoto Y, Chaipech S, Muraoka O, Morikawa T. |
タイトル | Labdane-Type Diterpenes, Galangalditerpenes A-C, with Melanogenesis Inhibitory Activity from the Fruit of Alpinia galanga. |
ジャーナル | Molecules |
Abstract |
In our continuing study of biologically active natural products from the fruit of Alpinia galanga (Zingiberaceae), we newly isolated three new labdane-type diterpenes, termed galangalditerpenes A-C (1-3), along with four known sesquiterpenes (4-7) and two diterpenes (8 and 9). The stereostructures of 1-3 were elucidated on the basis of their spectroscopic properties. The melanogenesis inhibitory activities in theophylline-stimulated murine B16 melanoma 4A5 cells of these isolates, including the new diterpenes (1-3, IC50 = 4.4, 8.6, and 4.6 μM, respectively), were found to be more than 6-87-fold higher than that of arbutin (174 μM), a commercially available positive control. |
巻・号 | 22(12) |
公開日 | 2017-12-20 |
DOI | 10.3390/molecules22122279 |
PII | molecules22122279 |
PMID | 29261124 |
PMC | PMC6149739 |
MeSH | Alpinia / chemistry* Animals Arbutin / chemistry Arbutin / pharmacology Cell Line, Tumor Cell Survival / drug effects Diterpenes / chemistry* Diterpenes / isolation & purification Diterpenes / pharmacology Fruit / chemistry* Melanins / metabolism* Melanoma, Experimental Mice Molecular Conformation Plant Extracts / chemistry Plant Extracts / isolation & purification Plant Extracts / pharmacology Sesquiterpenes / chemistry Sesquiterpenes / isolation & purification Sesquiterpenes / pharmacology Structure-Activity Relationship |
IF | 3.267 |
引用数 | 6 |
リソース情報 | |
ヒト・動物細胞 | B16 melanoma 4A5(RCB0557) |