Reference - Detail
| RRC ID | 52540 |
|---|---|
| Author | Kawashita Y, Morine Y, Saito Y, Takasu C, Ikemoto T, Iwahashi S, Teraoku H, Yoshikawa M, Imura S, Yagi T, Shimada M. |
| Title | Role of heat shock factor 1 expression in the microenvironment of intrahepatic cholangiocarcinomas. |
| Journal | J Gastroenterol Hepatol |
| Abstract |
BACKGROUND AND AIM:Heat shock factor 1 (HSF1), a master regulator of heat shock response, has been shown to play a multifaceted role in cancer progression. However, the clinical significance and biological effect of HSF1 expression in intrahepatic cholangiocarcinoma (IHCC) remain unknown. METHODS:Forty-nine patients with IHCC who underwent hepatic resection were enrolled in this study. HSF1 expression in tumor tissue was determined by immunohistochemistry, and patients were divided into two groups, those with high (n = 20) and low (n = 29) HSF1 expression. Clinicopathological factors including prognosis were compared in these two groups. RESULTS:HSF1 expression was significantly higher in tumors than in normal tissue. The overall survival rate was significantly lower in patients with high than low HSF1. Multivariate analysis showed that high HSF1 expression was a factor independently prognostic of patient survival. CONCLUSION:High HSF1 expression in tumor tissues may be a prognostic biomarker in patients with IHCC. |
| Volume | 33(7) |
| Pages | 1407-1412 |
| Published | 2018-7-1 |
| DOI | 10.1111/jgh.14078 |
| PMID | 29278438 |
| MeSH | Adult Aged Aged, 80 and over Bile Duct Neoplasms / genetics* Bile Duct Neoplasms / metabolism Bile Duct Neoplasms / mortality Bile Duct Neoplasms / pathology Cell Line, Tumor Cholangiocarcinoma / genetics* Cholangiocarcinoma / metabolism Cholangiocarcinoma / mortality Cholangiocarcinoma / pathology Disease Progression Female Gene Expression / genetics* Heat Shock Transcription Factors / genetics* Heat Shock Transcription Factors / metabolism Heat Shock Transcription Factors / physiology* Humans Immunohistochemistry Male Middle Aged Multivariate Analysis Prognosis Survival Rate Tumor Microenvironment / genetics* |
| IF | 3.483 |
| Times Cited | 0 |
| Resource | |
| Human and Animal Cells | HuCCT1(RCB1960) |