論文 - 詳細
| RRC ID | 52664 |
|---|---|
| 著者 | Mochimaru Y, Negishi J, Murakami S, Musha S, Sato K, Okajima F, Tomura H. |
| タイトル | Metals Differentially Activate Ovarian Cancer G Protein-Coupled Receptor 1 in Various Species. |
| ジャーナル | Zoolog Sci |
| Abstract |
Human, mouse, and zebrafish ovarian cancer G protein-coupled receptors (OGR1s) are activated by both metals and extracellular protons. In the present study, we examined whether pig, rat, chicken, and Xenopus OGR1 homologs could sense and be activated by protons and metals. We found that all homologs stimulated serum response element (SRE)-driven promoter activities when they are stimulated by protons. On the other hand, metals differentially activated the homologs. The results using chimeric receptors of human and zebrafish OGR1s indicate that the specificity of the metal-induced activation lies in the extracellular region. These results suggest that protons are an evolutionally conserved agonist of OGR1. However, the types of metals that activated the receptor differed among the homologs. |
| 巻・号 | 35(2) |
| ページ | 109-114 |
| 公開日 | 2018-4-1 |
| DOI | 10.2108/zs170145 |
| PMID | 29623784 |
| MeSH | Animals Chickens / genetics* Chickens / metabolism Female HEK293 Cells Humans Metals / administration & dosage* Ovarian Neoplasms / genetics Protons* Rats / genetics* Rats / metabolism Receptors, G-Protein-Coupled / genetics* Receptors, G-Protein-Coupled / metabolism Serum Response Element / drug effects Sus scrofa / genetics* Sus scrofa / metabolism Xenopus / genetics* Xenopus / metabolism |
| IF | 0.843 |
| 引用数 | 6 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | 293T(RCB2202) |