論文 - 詳細
| RRC ID | 52670 |
|---|---|
| 著者 | Yanaki M, Kobayashi M, Aruga A, Nomura M, Ozaki M. |
| タイトル | In Vivo Antitumor Effects of MK615 Led by PD-L1 Downregulation. |
| ジャーナル | Integr Cancer Ther |
| Abstract |
BACKGROUND/AIM:MK615 extracted from Prunus mume was reported to have anti-inflammatory effects. In this article, we examined the in vivo antitumor effect of MK615 (an extract from Japanese apricot) using mouse tumor xenografts and focusing on the downregulation of PD-L1 (programmed death-ligand 1), a ligand of programmed cell death-1, a surface protein of activated T cells. MATERIALS AND METHODS:B16/BL6 melanoma cells were injected into C57BL/6 or BALB/c-nu/nu mice to establish lung metastasis. BALB/c-nu/nu mice (nude mice) were used as a T cell-deficient model. The mice were given MK615 or saline orally every other day for approximately 8 weeks, and their survival was observed. NF-κB (nuclear factor-κB) and PD-L1 expressions of metastatic lung tissues were also examined. RESULTS:The survival rate was improved only in the MK615-treated C57BL/6 mice ( P < .05), not in the saline-given control mice or BALB/c-nu/nu mice. The downregulations of NF-κB and PD-L1 were observed in both MK615-treated C57BL/6 and BALB/c-nu/nu mice. These results suggest that the antitumor effects of MK615 are associated with T cell-mediated immunity activated by MK-615-induced PD-L1 downregulation in tumor cells. CONCLUSION:MK615 is beneficial for a prolonged host survival time in the B16/BL6 melanoma xenograft model associated with T cell-mediated antitumor immunity. |
| 巻・号 | 17(3) |
| ページ | 646-653 |
| 公開日 | 2018-9-1 |
| DOI | 10.1177/1534735418766403 |
| PMID | 29665734 |
| PMC | PMC6142083 |
| MeSH | Animals Antineoplastic Agents / pharmacology* B7-H1 Antigen / metabolism* Cell Line, Tumor Down-Regulation / drug effects* Heterografts / drug effects Male Melanoma, Experimental / drug therapy Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Nude NF-kappa B / metabolism Plant Extracts / pharmacology* Prunus / chemistry |
| IF | 2.657 |
| 引用数 | 3 |
| リソース情報 | |
| ヒト・動物細胞 | B16/BL6(RCB2638) |