Reference - Detail
| RRC ID | 52735 |
|---|---|
| Author | Ikegami K, Yoshimura T. |
| Title | The hypothalamic-pituitary-thyroid axis and biological rhythms: The discovery of TSH's unexpected role using animal models. |
| Journal | Best Pract Res Clin Endocrinol Metab |
| Abstract |
Thyroid hormones (TH) are important for development, growth, and metabolism. It is also clear that the synthesis and secretion of TH are regulated by the hypothalamic-pituitary-thyroid (HPT) axis. Animal models have helped advance our understanding of the roles and regulatory mechanisms of TH. The animals' bodies develop through coordinated timing of cell division and differentiation. Studies of frog metamorphosis led to the discovery of TH and their role in development. However, to adapt to rhythmic environmental changes, animals also developed various endocrine rhythms. Studies of rodents clarified the neural and molecular mechanisms underlying the circadian regulation of the HPT axis. Moreover, birds have a sophisticated seasonal adaptation mechanism, and recent studies of quail revealed unexpected roles for thyroid-stimulating hormone (TSH) and TH in the seasonal regulation of reproduction. Interestingly, this mechanism is conserved in mammals. Thus, we review how animal studies have shaped our general understanding of the HPT axis in relation to biological rhythms. |
| Volume | 31(5) |
| Pages | 475-485 |
| Published | 2017-10-1 |
| DOI | 10.1016/j.beem.2017.09.002 |
| PII | S1521-690X(17)30096-9 |
| Description | リソースを用いた研究成果としてどのように視床下部の研究が行われて来たのかを説明した。 |
| PMID | 29223282 |
| MeSH | Animals Birds Hypothalamo-Hypophyseal System / physiology* Models, Animal Thyroid Gland / physiology* Thyrotropin / physiology* |
| IF | 4.417 |
| Times Cited | 8 |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | Wikipedia |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Chicken / Quail | |