| RRC ID |
52786
|
| Author |
Toyotome T, Hagiwara D, Kida H, Ogi T, Watanabe A, Wada T, Komatsu R, Kamei K.
|
| Title |
First clinical isolation report of azole-resistant Aspergillus fumigatus with TR34/L98H-type mutation in Japan.
|
| Journal |
J Infect Chemother
|
| Abstract |
Recently, azole-resistant Aspergillus fumigatus containing a 34-bp or 46-bp tandem repeat in the promoter region of cyp51A combined with amino acid substitution(s) has appeared in the environment worldwide, including several Asian countries. In this study, we isolated the 34-bp tandem repeat-containing azole-resistant A. fumigatus strain OKH50 from a patient in Japan in May 2016. The patient had not been treated with medical azoles before the strain isolation, suggesting that the resistant property was acquired before infection. In addition, the patient had not traveled overseas. Our analysis of short tandem repeats of the strain indicates that the strain is strongly related to the 34-bp tandem repeat-containing isolates from European countries and Asia-Oceania countries but not to susceptible isolates from Japan, suggesting that the strain was introduced from overseas and might spread in Japan.
|
| Volume |
23(8)
|
| Pages |
579-581
|
| Published |
2017-8-1
|
| DOI |
10.1016/j.jiac.2016.12.004
|
| PII |
S1341-321X(16)30264-1
|
| PMID |
28109740
|
| MeSH |
Aged
Antifungal Agents / pharmacology*
Aspergillus fumigatus* / drug effects
Aspergillus fumigatus* / genetics
Aspergillus fumigatus* / isolation & purification
Azoles / pharmacology*
Cytochrome P-450 Enzyme System / genetics
Drug Resistance, Fungal / genetics*
Fungal Proteins / genetics
Humans
Japan
Male
Mutation / genetics
Pulmonary Aspergillosis / microbiology*
Sputum / microbiology
|
| IF |
1.539
|
| Times Cited |
11
|
| Resource |
| Pathogenic eukaryotic microorganisms |
病原真菌：IFM 59056, IFM 60514, IFM 59365, IFM 61407, IFM 60237, IFM 59073, IFM 59359, IFM 62351, IFM 64159 (= OKH31), IFM 64732 (= OKH50) |
