論文 - 詳細
| RRC ID | 52850 |
|---|---|
| 著者 | Jiang K, Otani M, Shimotakahara H, Yoon JM, Park SH, Miyaji T, Nakano T, Nakamura H, Nakajima M, Asami T. |
| タイトル | Substituted Phthalimide AC94377 Is a Selective Agonist of the Gibberellin Receptor GID1. |
| ジャーナル | Plant Physiol |
| Abstract |
Gibberellin (GA) is a major plant hormone that regulates plant growth and development and is widely used as a plant growth regulator in agricultural production. There is an increasing demand for function-limited GA mimics due to the limitations on the agronomical application of GA to crops, including GA's high cost of producing and its leading to the crops' lodging. AC94377, a substituted phthalimide, is a chemical that mimics the growth-regulating activity of GAs in various plants, despite its structural difference. Although AC94377 is widely studied in many weeds and crops, its mode of action as a GA mimic is largely unknown. In this study, we confirmed that AC94377 displays GA-like activities in Arabidopsis (Arabidopsis thaliana) and demonstrated that AC94377 binds to the Arabidopsis GIBBERELLIN INSENSITIVE DWARF1 (GID1) receptor (AtGID1), forms the AtGID1-AC94377-DELLA complex, and induces the degradation of DELLA protein. Our results also indicated that AC94377 is selective for a specific subtype among three AtGID1s and that the selectivity of AC94377 is attributable to a single residue at the entrance to the hydrophobic pocket of GID1. We conclude that AC94377 is a GID1 agonist with selectivity for a specific subtype of GID1, which could be further developed and used as a function-limited regulator of plant growth in both basic study and agriculture. |
| 巻・号 | 173(1) |
| ページ | 825-835 |
| 公開日 | 2017-1-1 |
| DOI | 10.1104/pp.16.00937 |
| PII | pp.16.00937 |
| PMID | 27899534 |
| PMC | PMC5210710 |
| MeSH | Arabidopsis / drug effects* Arabidopsis / metabolism Arabidopsis Proteins / agonists* Arabidopsis Proteins / chemistry Arabidopsis Proteins / genetics Arabidopsis Proteins / metabolism Germination / drug effects Gibberellins / metabolism Hypocotyl / drug effects Phthalimides / chemistry* Phthalimides / metabolism Phthalimides / pharmacology* Plants, Genetically Modified Receptors, Cell Surface / agonists* Receptors, Cell Surface / chemistry Receptors, Cell Surface / genetics Receptors, Cell Surface / metabolism Signal Transduction / drug effects Tobacco / genetics |
| IF | 6.902 |
| 引用数 | 6 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 9 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| シロイヌナズナ / 植物培養細胞・遺伝子 | psi00018 psi00021 |