| RRC ID |
52856
|
| Author |
Shinkai Y, Yoshida MC, Maeda K, Kobata T, Maruyama K, Yodoi J, Yagita H, Okumura K.
|
| Title |
Molecular cloning and chromosomal assignment of a human perforin (PFP) gene.
|
| Journal |
Immunogenetics
|
| Abstract |
Human perforin cDNA was isolated and the complete nucleotide sequence of the gene determined. The deduced amino acid sequence of human perforin showed 68.4% similarity to that of mouse perforin. RNA blot analysis of the human perforin gene revealed that the gene product is expressed preferentially in killer-type cells among cell lines tested, and in large granular lymphocytes among the peripheral blood mononuclear cells. In situ hybridization analysis with a human perforin cDNA probe revealed that the human perforin (PFP) gene is located on chromosome 17q11-21.
|
| Volume |
30(6)
|
| Pages |
452-7
|
| Published |
1989-1-1
|
| DOI |
10.1007/BF02421177
|
| PMID |
2592021
|
| MeSH |
Base Sequence
Blotting, Northern
Chromosome Mapping*
Chromosomes, Human, Pair 17
Cloning, Molecular*
DNA / isolation & purification
Humans
Membrane Glycoproteins*
Membrane Proteins / genetics*
Molecular Sequence Data
Perforin
Pore Forming Cytotoxic Proteins
|
| IF |
2.621
|
| Times Cited |
61
|
| Resource |
| DNA material |
YT101 (RDB01181). |
