論文 - 詳細
| RRC ID | 5308 |
|---|---|
| 著者 | Lee HK, Lund JM, Ramanathan B, Mizushima N, Iwasaki A. |
| タイトル | Autophagy-dependent viral recognition by plasmacytoid dendritic cells. |
| ジャーナル | Science |
| Abstract |
Plasmacytoid dendritic cells (pDCs) detect viruses in the acidified endosomes by means of Toll-like receptors (TLRs). Yet, pDC responses to certain single-stranded RNA (ssRNA) viruses occur only after live viral infection. We present evidence here that the recognition of such viruses by TLR7 requires transport of cytosolic viral replication intermediates into the lysosome by the process of autophagy. In addition, autophagy was found to be required for the production of interferon-alpha by pDCs. These results support a key role for autophagy in mediating ssRNA virus detection and interferon-alpha secretion by pDCs and suggest that cytosolic replication intermediates of viruses serve as pathogen signatures recognized by TLR7. |
| 巻・号 | 315(5817) |
| ページ | 1398-401 |
| 公開日 | 2007-3-9 |
| DOI | 10.1126/science.1136880 |
| PII | 1136880 |
| PMID | 17272685 |
| MeSH | Animals Autophagy* Dendritic Cells / immunology* Dendritic Cells / physiology Dendritic Cells / virology* Endosomes / immunology Endosomes / virology Female Immunity, Innate Interferon-alpha / metabolism Interleukin-12 / metabolism Lysosomes / virology Male Membrane Glycoproteins / immunology* Mice Mice, Transgenic Phagosomes / physiology Phagosomes / ultrastructure RNA, Viral / immunology* RNA, Viral / metabolism Rhabdoviridae Infections / immunology* Toll-Like Receptor 7 / immunology* Vesicular stomatitis Indiana virus / immunology* Vesicular stomatitis Indiana virus / physiology Virus Replication |
| IF | 41.846 |
| 引用数 | 633 |
| WOS 分野 | IMMUNOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | F1000Research |
| 各媒体での言及数の合計 | 16 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC00806 |