Reference - Detail
|Author||Imadome KI, Fujiwara S.|
|Title||Generation and Analysis of Humanized Mouse Model of EBV Infection.|
|Journal||Methods Mol. Biol.|
The recent development of severely immunodeficient mouse strains enabled the production of new-generation humanized mice, in which major components of the human immune system are reconstituted. These new-generation humanized mice can be infected with human pathogenic viruses that do not infect regular mice and target cells of the hematoimmune system. Here we describe the method for preparing humanized mice, infecting them with EBV, and for their virological and immunological analyses. The results obtained from our own mouse models are briefly described.
|MeSH||Animals Disease Models, Animal Epstein-Barr Virus Infections / immunology* Epstein-Barr Virus Infections / virology* Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells Herpesvirus 4, Human / immunology* Heterografts Histocompatibility Antigens Class I / chemistry Histocompatibility Antigens Class I / immunology Host-Pathogen Interactions / immunology* Humans Immune System / cytology Immune System / immunology Immune System / metabolism Lymphocytes / immunology Lymphocytes / metabolism Mice Mice, Inbred NOD Mice, Knockout Protein Multimerization Transplantation Chimera Viral Load|
|Cord blood stem cells for research|