| RRC ID |
53238
|
| Author |
Dong B, Moseley-Alldredge M, Schwieterman AA, Donelson CJ, McMurry JL, Hudson ML, Chen L.
|
| Title |
EFN-4 functions in LAD-2-mediated axon guidance in Caenorhabditis elegans.
|
| Journal |
Development
|
| Abstract |
During development of the nervous system, growing axons rely on guidance molecules to direct axon pathfinding. A well-characterized family of guidance molecules are the membrane-associated ephrins, which together with their cognate Eph receptors, direct axon navigation in a contact-mediated fashion. InC. elegans, the ephrin-Eph signaling system is conserved and is best characterized for their roles in neuroblast migration during early embryogenesis. This study demonstrates a role for the C. elegans ephrin EFN-4 in axon guidance. We provide both genetic and biochemical evidence that is consistent with the C. elegans divergent L1 cell adhesion molecule LAD-2 acting as a non-canonical ephrin receptor to EFN-4 to promote axon guidance. We also show that EFN-4 probably functions as a diffusible factor because EFN-4 engineered to be soluble can promote LAD-2-mediated axon guidance. This study thus reveals a potential additional mechanism for ephrins in regulating axon guidance and expands the repertoire of receptors by which ephrins can signal.
|
| Volume |
143(7)
|
| Pages |
1182-91
|
| Published |
2016-4-1
|
| DOI |
10.1242/dev.128934
|
| PII |
dev.128934
|
| PMID |
26903502
|
| PMC |
PMC4852490
|
| MeSH |
Animals
Axons / metabolism*
Caenorhabditis elegans / embryology*
Caenorhabditis elegans Proteins / genetics*
Cell Line
Ephrins / genetics*
HEK293 Cells
Humans
Membrane Proteins / metabolism
Metalloendopeptidases / metabolism
Morphogenesis
Nervous System / embryology*
Neural Cell Adhesion Molecule L1 / genetics*
Neurogenesis / physiology*
Receptors, Eph Family / genetics
Signal Transduction
|
| IF |
5.611
|
| Times Cited |
3
|
| Resource |
| C.elegans |
tm3056 |
