論文 - 詳細
| RRC ID | 53238 |
|---|---|
| 著者 | Dong B, Moseley-Alldredge M, Schwieterman AA, Donelson CJ, McMurry JL, Hudson ML, Chen L. |
| タイトル | EFN-4 functions in LAD-2-mediated axon guidance in Caenorhabditis elegans. |
| ジャーナル | Development |
| Abstract |
During development of the nervous system, growing axons rely on guidance molecules to direct axon pathfinding. A well-characterized family of guidance molecules are the membrane-associated ephrins, which together with their cognate Eph receptors, direct axon navigation in a contact-mediated fashion. InC. elegans, the ephrin-Eph signaling system is conserved and is best characterized for their roles in neuroblast migration during early embryogenesis. This study demonstrates a role for the C. elegans ephrin EFN-4 in axon guidance. We provide both genetic and biochemical evidence that is consistent with the C. elegans divergent L1 cell adhesion molecule LAD-2 acting as a non-canonical ephrin receptor to EFN-4 to promote axon guidance. We also show that EFN-4 probably functions as a diffusible factor because EFN-4 engineered to be soluble can promote LAD-2-mediated axon guidance. This study thus reveals a potential additional mechanism for ephrins in regulating axon guidance and expands the repertoire of receptors by which ephrins can signal. |
| 巻・号 | 143(7) |
| ページ | 1182-91 |
| 公開日 | 2016-4-1 |
| DOI | 10.1242/dev.128934 |
| PII | dev.128934 |
| PMID | 26903502 |
| PMC | PMC4852490 |
| MeSH | Animals Axons / metabolism* Caenorhabditis elegans / embryology* Caenorhabditis elegans Proteins / genetics* Cell Line Ephrins / genetics* HEK293 Cells Humans Membrane Proteins / metabolism Metalloendopeptidases / metabolism Morphogenesis Nervous System / embryology* Neural Cell Adhesion Molecule L1 / genetics* Neurogenesis / physiology* Receptors, Eph Family / genetics Signal Transduction |
| IF | 5.611 |
| 引用数 | 3 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm3056 |