論文 - 詳細
| RRC ID | 53256 |
|---|---|
| 著者 | Jang S, Nelson JC, Bend EG, Rodríguez-Laureano L, Tueros FG, Cartagenova L, Underwood K, Jorgensen EM, Colón-Ramos DA. |
| タイトル | Glycolytic Enzymes Localize to Synapses under Energy Stress to Support Synaptic Function. |
| ジャーナル | Neuron |
| Abstract |
Changes in neuronal activity create local and transient changes in energy demands at synapses. Here we discover a metabolic compartment that forms in vivo near synapses to meet local energy demands and support synaptic function in Caenorhabditis elegans neurons. Under conditions of energy stress, glycolytic enzymes redistribute from a diffuse localization in the cytoplasm to a punctate localization adjacent to synapses. Glycolytic enzymes colocalize, suggesting the ad hoc formation of a glycolysis compartment, or a "glycolytic metabolon," that can maintain local levels of ATP. Local formation of the glycolytic metabolon is dependent on presynaptic scaffolding proteins, and disruption of the glycolytic metabolon blocks the synaptic vesicle cycle, impairs synaptic recovery, and affects locomotion. Our studies indicate that under energy stress conditions, energy demands in C. elegans synapses are met locally through the assembly of a glycolytic metabolon to sustain synaptic function and behavior. VIDEO ABSTRACT. |
| 巻・号 | 90(2) |
| ページ | 278-91 |
| 公開日 | 2016-4-20 |
| DOI | 10.1016/j.neuron.2016.03.011 |
| PII | S0896-6273(16)00211-7 |
| PMID | 27068791 |
| PMC | PMC4840048 |
| MeSH | Animals Caenorhabditis elegans / cytology* Caenorhabditis elegans / enzymology* Caenorhabditis elegans / metabolism Endocytosis Hypoxia Metabolomics Mutation Phosphofructokinase-1 / metabolism* Presynaptic Terminals / enzymology* Presynaptic Terminals / metabolism Presynaptic Terminals / physiology* Stress, Physiological* Synaptic Vesicles / enzymology Synaptic Vesicles / metabolism |
| IF | 14.415 |
| 引用数 | 82 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 39 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm5782 tm5613 tm408 |