論文 - 詳細
| RRC ID | 53261 |
|---|---|
| 著者 | Yu Y, Zhi L, Wu Q, Jing L, Wang D. |
| タイトル | NPR-9 regulates the innate immune response in Caenorhabditis elegans by antagonizing the activity of AIB interneurons. |
| ジャーナル | Cell Mol Immunol |
| Abstract |
npr-9 encodes a homologue of the gastrin-releasing peptide receptor (GRPR) and is expressed in AIB interneurons. In this study, we investigated the role of NPR-9 in the neuronal control of innate immunity using the model system Caenorhabditis elegans. After exposure to Pseudomonas aeruginosa PA14, npr-9(tm1652) mutants showed resistance to infection, decreased PA14 colonization and increased expression of immunity-related genes. Nematodes overexpressing NPR-9 exhibited increased susceptibility to infection, increased PA14 colonization and reduced expression of immunity-related genes. In nematodes, ChR2-mediated AIB interneuron activation strengthened the innate immune response and decreased PA14 colonization. Overexpression of NPR-9 suppressed the innate immune response and increased PA14 colonization in nematodes with the activation of AIB interneurons mediated by ChR2 or by expressing pkc-1(gf) in AIB interneurons. We, therefore, hypothesize that NPR-9 regulates the innate immune response by antagonizing the activity of AIB interneurons. Furthermore, expression of GRPR, the human homologue of NPR-9, could largely mimic NPR-9 function by regulating innate immunity in nematodes. Our results provide insight into the pivotal role of interneurons in controlling innate immunity and the complex biological functions of GRPRs. |
| 巻・号 | 15(1) |
| ページ | 27-37 |
| 公開日 | 2018-1-1 |
| DOI | 10.1038/cmi.2016.8 |
| PII | cmi20168 |
| PMID | 27133473 |
| PMC | PMC5827173 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / immunology* Caenorhabditis elegans / microbiology Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Epistasis, Genetic Humans Immunity, Innate* Interneurons / metabolism* Mutation / genetics Optogenetics Pseudomonas Infections / immunology Pseudomonas aeruginosa / physiology Receptors, G-Protein-Coupled / genetics Receptors, G-Protein-Coupled / metabolism* |
| IF | 8.484 |
| 引用数 | 7 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1652 |