RRC ID 53287
Author Sonoda S, Ohta A, Maruo A, Ujisawa T, Kuhara A.
Title Sperm Affects Head Sensory Neuron in Temperature Tolerance of Caenorhabditis elegans.
Journal Cell Rep
Abstract Tolerance to environmental temperature change is essential for the survival and proliferation of animals. The process is controlled by various body tissues, but the orchestration of activity within the tissue network has not been elucidated in detail. Here, we show that sperm affects the activity of temperature-sensing neurons (ASJ) that control cold tolerance in Caenorhabditis elegans. Genetic impairment of sperm caused abnormal cold tolerance, which was unexpectedly restored by impairment of temperature signaling in ASJ neurons. Calcium imaging revealed that ASJ neuronal activity in response to temperature was decreased in sperm mutant gsp-4 with impaired protein phosphatase 1 and rescued by expressing gsp-4 in sperm. Genetic analysis revealed a feedback network in which ASJ neuronal activity regulates the intestine through insulin and a steroid hormone, which then affects sperm and, in turn, controls ASJ neuronal activity. Thus, we propose that feedback between sperm and a sensory neuron mediating temperature tolerance.
Volume 16(1)
Pages 56-65
Published 2016-6-28
DOI 10.1016/j.celrep.2016.05.078
PII S2211-1247(16)30691-X
PMID 27320929
MeSH Adaptation, Physiological* Animals Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism Calcium / metabolism Cold Temperature* Head Intestines / physiology Male Models, Biological Organ Specificity Receptors, Cell Surface / metabolism Sensory Receptor Cells / physiology* Signal Transduction Spermatozoa / physiology* Steroids / metabolism
IF 8.109
Times Cited 10
Resource
C.elegans tm1647 tm5415 tm886 tm1033 tm6661 tm1819 tm2174 tm1185 tm1698 tm699