RRC ID 53291
Author Tao J, Ma YC, Yang ZS, Zou CG, Zhang KQ.
Title Octopamine connects nutrient cues to lipid metabolism upon nutrient deprivation.
Journal Sci Adv
Abstract Starvation is probably the most common stressful situation in nature. In vertebrates, elevation of the biogenic amine norepinephrine levels is common during starvation. However, the precise role of norepinephrine in nutrient deprivation remains largely unknown. We report that in the free-living nematode Caenorhabditis elegans, up-regulation of the biosynthesis of octopamine, the invertebrate counterpart of norepinephrine, serves as a mechanism to adapt to starvation. During nutrient deprivation, the nuclear receptor DAF-12, known to sense nutritional cues, up-regulates the expression of tbh-1 that encodes tyramine β-hydroxylase, a key enzyme for octopamine biosynthesis, in the RIC neurons. Octopamine induces the expression of the lipase gene lips-6 via its receptor SER-3 in the intestine. LIPS-6, in turn, elicits lipid mobilization. Our findings reveal that octopamine acts as an endocrine regulator linking nutrient cues to lipolysis to maintain energy homeostasis, and suggest that such a mechanism may be evolutionally conserved in diverse organisms.
Volume 2(5)
Pages e1501372
Published 2016-5-1
DOI 10.1126/sciadv.1501372
PII 1501372
PMID 27386520
PMC PMC4928904
MeSH Animals Caenorhabditis elegans Caenorhabditis elegans Proteins / metabolism Cues* Food* Gene Expression Regulation Lipase / genetics Lipase / metabolism Lipid Metabolism* Metabolic Networks and Pathways Nutritional Physiological Phenomena* Octopamine / metabolism* Protein Binding Starvation*
IF 13.117
Times Cited 18
C.elegans tm2146 tm3116