論文 - 詳細
| RRC ID | 53315 |
|---|---|
| 著者 | Cao X, Aballay A. |
| タイトル | Neural Inhibition of Dopaminergic Signaling Enhances Immunity in a Cell-Non-autonomous Manner. |
| ジャーナル | Curr Biol |
| Abstract |
The innate immune system is the front line of host defense against microbial infections, but its rapid and uncontrolled activation elicits microbicidal mechanisms that have deleterious effects [1, 2]. Increasing evidence indicates that the metazoan nervous system, which responds to stimuli originating from both the internal and the external environment, functions as a modulatory apparatus that controls not only microbial killing pathways but also cellular homeostatic mechanisms [3-5]. Here we report that dopamine signaling controls innate immune responses through a D1-like dopamine receptor, DOP-4, in Caenorhabditis elegans. Chlorpromazine inhibition of DOP-4 in the nervous system activates a microbicidal PMK-1/p38 mitogen-activated protein kinase signaling pathway that enhances host resistance against bacterial infections. The immune inhibitory function of dopamine originates in CEP neurons and requires active DOP-4 in downstream ASG neurons. Our findings indicate that dopamine signaling from the nervous system controls immunity in a cell-non-autonomous manner and identifies the dopaminergic system as a potential therapeutic target for not only infectious diseases but also a range of conditions that arise as a consequence of malfunctioning immune responses. |
| 巻・号 | 26(17) |
| ページ | 2329-34 |
| 公開日 | 2016-9-12 |
| DOI | 10.1016/j.cub.2016.06.036 |
| PII | S0960-9822(16)30675-3 |
| PMID | 27524480 |
| PMC | PMC5021569 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism Chlorpromazine / pharmacology Dopamine / physiology* Dopamine Antagonists / pharmacology Immunity, Innate* Neural Inhibition Neurons / physiology Receptors, Dopamine D2 / genetics* Receptors, Dopamine D2 / metabolism Signal Transduction* |
| IF | 9.601 |
| 引用数 | 21 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 24 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1392 |