RRC ID 53327
Author Wang Y, Zhang Y, Chen L, Liang Q, Yin XM, Miao L, Kang BH, Xue D.
Title Kinetics and specificity of paternal mitochondrial elimination in Caenorhabditis elegans.
Journal Nat Commun
Abstract In most eukaryotes, mitochondria are inherited maternally. The autophagy process is critical for paternal mitochondrial elimination (PME) in Caenorhabditis elegans, but how paternal mitochondria, but not maternal mitochondria, are selectively targeted for degradation is poorly understood. Here we report that mitochondrial dynamics have a profound effect on PME. A defect in fission of paternal mitochondria delays PME, whereas a defect in fusion of paternal mitochondria accelerates PME. Surprisingly, a defect in maternal mitochondrial fusion delays PME, which is reversed by a fission defect in maternal mitochondria or by increasing maternal mitochondrial membrane potential using oligomycin. Electron microscopy and tomography analyses reveal that a proportion of maternal mitochondria are compromised when they fail to fuse normally, leading to their competition for the autophagy machinery with damaged paternal mitochondria and delayed PME. Our study indicates that mitochondrial dynamics play a critical role in regulating both the kinetics and the specificity of PME.
Volume 7
Pages 12569
Published 2016-9-1
DOI 10.1038/ncomms12569
PII ncomms12569
PMID 27581092
PMC PMC5025750
MeSH Animals Autophagy / physiology* Caenorhabditis elegans / embryology Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Membrane Potential, Mitochondrial / drug effects Mitochondria / physiology* Mitochondrial Dynamics / physiology* Oligomycins / pharmacology Uncoupling Agents / pharmacology
IF 12.121
Times Cited 22
C.elegans tm1133 tm1108