RRC ID 53329
Author Chen D, Taylor KP, Hall Q, Kaplan JM.
Title The Neuropeptides FLP-2 and PDF-1 Act in Concert To Arouse Caenorhabditis elegans Locomotion.
Journal Genetics
Abstract During larval molts, Caenorhabditis elegans exhibits a sleep-like state (termed lethargus) that is characterized by the absence of feeding and profound locomotion quiescence. The rhythmic pattern of locomotion quiescence and arousal linked to the molting cycle is mediated by reciprocal changes in sensory responsiveness, whereby arousal is associated with increased responsiveness. Sensory neurons arouse locomotion via release of a neuropeptide (PDF-1) and glutamate. Here we identify a second arousing neuropeptide (FLP-2). We show that FLP-2 acts via an orexin-like receptor (FRPR-18), and that FLP-2 and PDF-1 secretion are regulated by reciprocal positive feedback. These results suggest that the aroused behavioral state is stabilized by positive feedback between two neuropeptides.
Volume 204(3)
Pages 1151-1159
Published 2016-11-1
DOI 10.1534/genetics.116.192898
PII genetics.116.192898
PMID 27585848
PMC PMC5105848
MeSH Animals Arousal* Caenorhabditis elegans / genetics* Caenorhabditis elegans / metabolism Caenorhabditis elegans / physiology Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism Feedback, Physiological Glutamic Acid / metabolism Locomotion* Neuropeptides / genetics* Neuropeptides / metabolism Orexin Receptors / genetics Orexin Receptors / metabolism Sensory Receptor Cells / metabolism Sensory Receptor Cells / physiology
IF 4.015
Times Cited 27
C.elegans tm1996